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NNR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855521, updated on 22-Aug-2024

Summary

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Official Symbol
NNR1
Primary source
FungiDB:YNL200C
Locus tag
YNL200C
See related
SGD:S000005144; AllianceGenome:SGD:S000005144; VEuPathDB:YNL200C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables NADHX epimerase activity. Involved in nicotinamide nucleotide metabolic process. Located in mitochondrion. Orthologous to several human genes including NAXE (NAD(P)HX epimerase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NNR1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (263713..264453, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene 2,4-dienoyl-CoA reductase (NADPH) Neighboring gene Psy2p Neighboring gene Gcr2p Neighboring gene mRNA-binding protein WHI3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. Marbaix AY, et al. J Biol Chem, 2011 Dec 2. PMID 21994945, Free PMC Article
  2. Stress response and expression patterns in wine fermentations of yeast genes induced at the diauxic shift. Puig S, et al. Yeast, 2000 Jan 30. PMID 10641036
  3. Genomic expression program involving the Haa1p-regulon in Saccharomyces cerevisiae response to acetic acid. Mira NP, et al. OMICS, 2010 Oct. PMID 20955010, Free PMC Article
  4. Genetic basis for Saccharomyces cerevisiae biofilm in liquid medium. Scherz K, et al. G3 (Bethesda), 2014 Jul 9. PMID 25009170, Free PMC Article
  5. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Philippsen P, et al. Nature, 1997 May 29. PMID 9169873

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NADHX epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADHX epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADHX epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADPHX epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nicotinamide nucleotide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADHX epimerase
NP_014199.1
  • NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    263713..264453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183038.1 → NP_014199.1  TPA: NADHX epimerase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014199.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0Y8, P40165
    UniProtKB/TrEMBL
    A6ZRN8, B3LP46, B5VQL0, C7GTH0, C8ZG31, G2WLR1, N1P452
    Conserved Domains (1) summary
    TIGR00197
    Location:5 → 224
    yjeF_nterm; yjeF N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40165.1

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