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SWT21 Swt21p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855534, updated on 2-Nov-2024

Summary

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Official Symbol
SWT21
Official Full Name
Swt21p
Primary source
SGD:S000005131
Locus tag
YNL187W
See related
AllianceGenome:SGD:S000005131; FungiDB:YNL187W; VEuPathDB:YNL187W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mRNA splicing, via spliceosome. Located in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 3; colorectal cancer; head and neck squamous cell carcinoma; lung non-small cell carcinoma; and ovarian cancer. Orthologous to human WRAP53 (WD repeat containing antisense to TP53). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SWT21 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (287994..289067)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene karyopherin alpha Neighboring gene Kar1p Neighboring gene ubiquitin-specific protease UBP10 Neighboring gene mitochondrial 54S ribosomal protein YmL19 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing. Murphy MW, et al. Genetics, 2004 Jan. PMID 15020406, Free PMC Article
  2. A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction. Hage R, et al. Mol Cell Biol, 2009 Jul. PMID 19451230, Free PMC Article
  3. Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors. Schwer B, et al. Nucleic Acids Res, 2013 Aug. PMID 23754852, Free PMC Article
  4. Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA. Qiu ZR, et al. RNA, 2012 Nov. PMID 23002122, Free PMC Article
  5. Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways. Hausmann S, et al. J Biol Chem, 2008 Nov 14. PMID 18775984, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Swt21p
NP_014212.1
  • Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    287994..289067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183025.1 → NP_014212.1  TPA: Swt21p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014212.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZRQ0, B3LP36, B5VQM2, C8ZG43, D6W100, P53873
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53873.1

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