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RIA1 GTPase RIA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855558, updated on 18-Sep-2024

Summary

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Official Symbol
RIA1
Official Full Name
GTPase RIA1
Primary source
SGD:S000005107
Locus tag
YNL163C
See related
AllianceGenome:SGD:S000005107; FungiDB:YNL163C; VEuPathDB:YNL163C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
EFL1
Summary
Enables GTPase activity. Involved in mature ribosome assembly. Located in cytoplasm. Human ortholog(s) of this gene implicated in Shwachman-Diamond syndrome. Orthologous to human EFL1 (elongation factor like GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RIA1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (326741..330073, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ibd2p Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L42A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of eIF6-mediated inhibition of ribosomal subunit joining. Gartmann M, et al. J Biol Chem, 2010 May 14. PMID 20356839, Free PMC Article
  2. Cooperative energetic effects elicited by the yeast Shwachman-Diamond syndrome protein (Sdo1) and guanine nucleotides modulate the complex conformational landscape of the elongation factor-like 1 (Efl1) GTPase. Luviano A, et al. Biophys Chem, 2019 Apr. PMID 30780079
  3. Ria1p (Ynl163c), a protein similar to elongation factors 2, is involved in the biogenesis of the 60S subunit of the ribosome in Saccharomyces cerevisiae. Bécam AM, et al. Mol Genet Genomics, 2001 Nov. PMID 11713675
  4. Functional analysis of the uL11 protein impact on translational machinery. Wawiórka L, et al. Cell Cycle, 2016. PMID 26939941, Free PMC Article
  5. Direct interaction between EFL1 and SBDS is mediated by an intrinsically disordered insertion domain. Asano N, et al. Biochem Biophys Res Commun, 2014 Jan 24. PMID 24406167

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mutual effects of Sdo1 and nucleotides on Efl1 modulate in a very specific and robust way the complex conformational landscape of Efl1, resembling the behavior observed with other GTPases and their cofactors.
    Title: Cooperative energetic effects elicited by the yeast Shwachman-Diamond syndrome protein (Sdo1) and guanine nucleotides modulate the complex conformational landscape of the elongation factor-like 1 (Efl1) GTPase.
  2. Sdo1 appears to function within a pathway containing elongation factor-like 1, and together they control translational activation of ribosomes.
    Title: The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytosolic ribosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytosolic ribosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytosolic ribosome assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GTPase RIA1
NP_014236.1
  • Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, a guanine nucleotide exchange factor (GEF), promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    326741..330073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183001.1 → NP_014236.1  TPA: GTPase RIA1 [Saccharomyces cerevisiae S288C]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W119, P53893
    UniProtKB/TrEMBL
    B3LP19, C7GTE0, E9PAB2, N1NXS8
    Conserved Domains (1) summary
    cl30786
    Location:1 → 1091
    FusA; Translation elongation factor EF-G, a GTPase [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53893.1

Gene LinkOut

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