ASI2 Asi2p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ASI2
Official Full Name: Asi2p
Primary source: SGD:S000005103
Locus tag: YNL159C
See related: AllianceGenome:SGD:S000005103; FungiDB:YNL159C; VEuPathDB:YNL159C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in cellular response to amino acid stimulus and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nuclear inner membrane. Part of Asi complex. [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Asi2 is ubiquitylated in a Ubc6-, Ubc7- and Doa10-dependent manner and is subsequently targeted for degradation by proteasomes in the nucleus.
Title: A nuclear ubiquitin-proteasome pathway targets the inner nuclear membrane protein Asi2 for degradation.
atypical ubiquitylation in yeast targets lysine-less Asi2 for proteasomal degradation
Title: Atypical ubiquitylation in yeast targets lysine-less Asi2 for proteasomal degradation.
Asi1, Asi2, and Asi3 work together to maintain the latent properties of transcription factors Stp1 and Stp2
Title: Inner nuclear membrane proteins Asi1, Asi2, and Asi3 function in concert to maintain the latent properties of transcription factors Stp1 and Stp2.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Asi complex	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_014240.1

Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and inner for ubiquitin-mediated degradation; acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids