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IGO1 phosphatase regulator [ Saccharomyces cerevisiae S288C ]

Gene ID: 855565, updated on 29-Jun-2024

Summary

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Gene symbol
IGO1
Gene description
phosphatase regulator
Primary source
FungiDB:YNL157W
Locus tag
YNL157W
See related
SGD:S000005101; AllianceGenome:SGD:S000005101; VEuPathDB:YNL157W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine phosphatase inhibitor activity. Involved in mRNA stabilization; positive regulation of cell cycle process; and regulation of cellular protein metabolic process. Located in P-body and nucleus. Orthologous to human ARPP19 (cAMP regulated phosphoprotein 19) and ENSA (endosulfine alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See IGO1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (340352..340858)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Asi2p Neighboring gene Pga1p Neighboring gene Nsg2p Neighboring gene uncharacterized protein Neighboring gene Cuz1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A phosphatase-centric mechanism drives stress signaling response. Hollenstein DM, et al. EMBO Rep, 2021 Nov 4. PMID 34558777, Free PMC Article
  2. The Rim15-endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast. Sarkar S, et al. PLoS Genet, 2014 Jun. PMID 24968058, Free PMC Article
  3. Quantification of mRNA stability of stress-responsive yeast genes following conditional excision of open reading frames. Talarek N, et al. RNA Biol, 2013 Aug. PMID 23792549, Free PMC Article
  4. Yeast endosulfines control entry into quiescence and chronological life span by inhibiting protein phosphatase 2A. Bontron S, et al. Cell Rep, 2013 Jan 31. PMID 23273919
  5. Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs. Luo X, et al. RNA Biol, 2011 Jan-Feb. PMID 21289492

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We propose that the Rim15-Endosulfine( Igo1 and Igo2 )-PP2ACdc55 signalling module triggers entry into quiescence and gametogenesis by regulating dephosphorylation of distinct substrates
    Title: The Rim15-endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast.
  2. Igo1/Igo2 can inhibit Cdc55 in early mitosis, but their contribution to Cdc55 regulation is relatively minor compared with the role of Zds1/Zds2.
    Title: Comparative genetic analysis of PP2A-Cdc55 regulators in budding yeast.
  3. We conclude that Greatwall, endosulfines((Igo1 and Igo2), and PP2A are part of a regulatory module that has been conserved during evolution irrespective of PP2A function in the control of mitosis
    Title: Budding yeast greatwall and endosulfines control activity and spatial regulation of PP2A(Cdc55) for timely mitotic progression.
  4. The mRNA decapping pathway targets heat shock protein 26 (HSP26) mRNAs in the absence of Igo1 and Igo2.
    Title: Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to heat IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA stabilization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G1 to G0 transition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle phase transition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein dephosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatase regulator
NP_014242.1
  • Protein required for initiation of the G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylation (S63) by Rim15p increases interaction with and inhibition of PP2A-Cdc55 for timely mitotic progression; can also activate PP2A-Cdc55 complexes and influence Cdc55p localization along with Igo2p; GFP protein localizes to the cytoplasm and nucleus; IGO1 has a paralog, IGO2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    340352..340858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182995.1 → NP_014242.1  TPA: phosphatase regulator [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014242.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W126, P53897
    UniProtKB/TrEMBL
    A0A6A5Q5E4, A6ZRS7, B3LP12, C7GXV7, C8ZG72, G2WLV0, N1NZA5
    Conserved Domains (1) summary
    pfam04667
    Location:27 → 109
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53897.1

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