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NSG2 Nsg2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855566, updated on 2-Nov-2024

Summary

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Official Symbol
NSG2
Official Full Name
Nsg2p
Primary source
SGD:S000005100
Locus tag
YNL156C
See related
AllianceGenome:SGD:S000005100; FungiDB:YNL156C; VEuPathDB:YNL156C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables unfolded protein binding activity. Involved in sterol biosynthetic process. Located in endoplasmic reticulum. Orthologous to human INSIG1 (insulin induced gene 1) and INSIG2 (insulin induced gene 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NSG2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (341069..341968, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pga1p Neighboring gene phosphatase regulator Neighboring gene uncharacterized protein Neighboring gene Cuz1p Neighboring gene serine/threonine protein kinase YCK2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. Theesfeld CL, et al. J Biol Chem, 2013 Mar 22. PMID 23306196, Free PMC Article
  2. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. Flury I, et al. EMBO J, 2005 Nov 16. PMID 16270032, Free PMC Article
  3. Genome-wide association across Saccharomyces cerevisiae strains reveals substantial variation in underlying gene requirements for toxin tolerance. Sardi M, et al. PLoS Genet, 2018 Feb. PMID 29474395, Free PMC Article
  4. Uptake of inorganic phosphate is a limiting factor for Saccharomyces cerevisiae during growth at low temperatures. Vicent I, et al. FEMS Yeast Res, 2015 May. PMID 25725023
  5. PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response. Ferrari E, et al. Mol Cell, 2017 Jul 20. PMID 28648781, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sterol biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nsg2p
NP_014243.3
  • Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; NSG2 has a paralog, NSG1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    341069..341968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182994.3 → NP_014243.3  TPA: Nsg2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014243.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W127, P53898
    UniProtKB/TrEMBL
    A6ZRS8, B3LP11, B5VQP8, C7GXV6, C8ZG73, N1NXD0
    Conserved Domains (1) summary
    pfam07281
    Location:116 → 296
    INSIG; Insulin-induced protein (INSIG)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53898.1

Gene LinkOut

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