U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CUZ1 Cuz1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855567, updated on 29-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
CUZ1
Gene description
Cuz1p
Primary source
FungiDB:YNL155W
Locus tag
YNL155W
See related
SGD:S000005099; AllianceGenome:SGD:S000005099; VEuPathDB:YNL155W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables proteasome binding activity. Involved in cellular response to arsenic-containing substance and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Orthologous to several human genes including ZFAND1 (zinc finger AN1-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CUZ1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (342516..343340)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene phosphatase regulator Neighboring gene Nsg2p Neighboring gene uncharacterized protein Neighboring gene serine/threonine protein kinase YCK2 Neighboring gene tubulin-binding prefolding complex subunit GIM3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Solution Structure of the Cuz1 AN1 Zinc Finger Domain: An Exposed LDFLP Motif Defines a Subfamily of AN1 Proteins. Sun ZJ, et al. PLoS One, 2016. PMID 27662200, Free PMC Article
  2. Genomic-scale comparison of sequence- and structure-based methods of function prediction: does structure provide additional insight? Fetrow JS, et al. Protein Sci, 2001 May. PMID 11316881, Free PMC Article
  3. Disruption and basic phenotypic analysis of six novel genes from the left arm of chromosome XIV of Saccharomyces cerevisiae. Dueñas E, et al. Yeast, 1999 Jan 15. PMID 10028186
  4. Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity. Hanna J, et al. J Biol Chem, 2014 Jan 17. PMID 24297164, Free PMC Article
  5. Unraveling networks of co-regulated genes on the sole basis of genome sequences. Brohée S, et al. Nucleic Acids Res, 2011 Aug. PMID 21572103, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cuz1/Ynl155w is proposed to protect cells from metalloid-induced proteotoxicity by delivering ubiquitinated substrates to Cdc48 and the proteasome for destruction.
    Title: Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity.
  2. Cuz1 helps limit the accumulation of ubiquitin conjugates on both the proteasome and Cdc48, suggesting a possible role in the transfer of ubiquitylated substrates from Cdc48 to the proteasome
    Title: A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables proteasome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to arsenic-containing substance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to arsenic-containing substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Cuz1p
NP_014244.1
  • Protein with a role in the ubiquitin-proteasome pathway; interacts with ubiquitinated protein, Cdc48p and the proteasomal regulatory particle; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element and is co-regulated with proteasome subunit genes; AN1-type zinc finger protein, with DHHC and ubiquitin-like domains (UBL); ortholog of ZFAND1, a human gene linked to cancer; protein abundance increases under DNA replication stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    342516..343340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182993.1 → NP_014244.1  TPA: Cuz1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014244.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W128, P53899
    UniProtKB/TrEMBL
    A0A8H4BXR8, B3LP10, C7GXV5, C8ZG74, N1NWH3
    Conserved Domains (2) summary
    smart00154
    Location:18 → 55
    ZnF_AN1; AN1-like Zinc finger
    COG3582
    Location:90 → 274
    COG3582; Predicted nucleic acid binding protein containing the AN1-type Zn-finger [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53899.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools