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FPR1 peptidylprolyl isomerase FPR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855587, updated on 18-Sep-2024

Summary

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Official Symbol
FPR1
Official Full Name
peptidylprolyl isomerase FPR1
Primary source
SGD:S000005079
Locus tag
YNL135C
See related
AllianceGenome:SGD:S000005079; FungiDB:YNL135C; VEuPathDB:YNL135C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FKB1; RBP1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; macrolide binding activity; and peptidyl-prolyl cis-trans isomerase activity. Involved in several processes, including protein folding; regulation of homoserine biosynthetic process; and transcription by RNA polymerase II. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to several human genes including FKBP1A (FKBP prolyl isomerase 1A) and FKBP1B (FKBP prolyl isomerase 1B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FPR1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (371882..372226, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein NAM9 Neighboring gene Eaf7p Neighboring gene uncharacterized protein Neighboring gene Fyv6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis. Rotonda J, et al. J Biol Chem, 1993 Apr 15. PMID 7681823
  2. Screening of small molecule interactor library by using in-cell NMR spectroscopy (SMILI-NMR). Xie J, et al. J Med Chem, 2009 Jun 11. PMID 19422228, Free PMC Article
  3. Cloning and sequence analysis of a rapamycin-binding protein-encoding gene (RBP1) from Candida albicans. Ferrara A, et al. Gene, 1992 Apr 1. PMID 1563628
  4. FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins. Wiederrecht G, et al. Proc Natl Acad Sci U S A, 1991 Feb 1. PMID 1704127, Free PMC Article
  5. FPR1 is essential for rapamycin-induced lifespan extension in Saccharomyces cerevisiae. Yalcin G, et al. Biochem Biophys Res Commun, 2023 Apr 23. PMID 36857903

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FPR1 is essential for rapamycin-induced lifespan extension in Saccharomyces cerevisiae.
    Title: FPR1 is essential for rapamycin-induced lifespan extension in Saccharomyces cerevisiae.
  2. Saccharomyces cerevisiae Fpr1 functions as a chaperone to inhibit protein aggregation.
    Title: Saccharomyces cerevisiae Fpr1 functions as a chaperone to inhibit protein aggregation.
  3. Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast.
    Title: Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast.
  4. Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae.
    Title: Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae.
  5. mutation or inhibition of FKBP12 dysregulates the homoserine synthetic pathway by perturbing aspartokinase feedback inhibition by threonine
    Title: FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables macrolide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nonfunctional rRNA decay IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of homoserine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
peptidylprolyl isomerase FPR1
NP_014264.1
  • Peptidyl-prolyl cis-trans isomerase (PPIase); binds to FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; associates with promoters of ribosomal protein genes; acts as chaperone to prevent protein aggregation; N-terminally propionylated in vivo; mutation is functionally complemented by human FKBP1A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    371882..372226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182973.1 → NP_014264.1  TPA: peptidylprolyl isomerase FPR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014264.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W147, P20081
    UniProtKB/TrEMBL
    A6ZRU8, B3LNZ2, C7GKB2, C8ZG95, G2WLX1, N1NZB8
    Conserved Domains (1) summary
    COG0545
    Location:1 → 114
    FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20081.2

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