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uncharacterized protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 855615, updated on 18-Sep-2024

Summary

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Official Full Name
uncharacterized protein
Primary source
SGD:S000005052
Locus tag
YNL108C
See related
AllianceGenome:SGD:S000005052; FungiDB:YNL108C; VEuPathDB:YNL108C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HUF
Summary
Enables phosphatase activity. Involved in dephosphorylation. Located in cytoplasm and nucleus. Orthologous to human UBASH3A (ubiquitin associated and SH3 domain containing A) and UBASH3B (ubiquitin associated and SH3 domain containing B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (419014..419826, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Cyb5p Neighboring gene rRNA-binding ribosome biosynthesis protein NOP15 Neighboring gene YEATS domain-containing protein YAF9 Neighboring gene phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Detection of modifications in the glucose metabolism induced by genetic mutations in Saccharomyces cerevisiae by 13C- and H-NMR spectroscopy. Herve M, et al. Eur J Biochem, 2000 Jun. PMID 10824121
  2. Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC. Taylor NM, et al. J Biol Chem, 2013 May 24. PMID 23569204, Free PMC Article
  3. A chimeric subunit of yeast transcription factor IIIC forms a subcomplex with tau95. Manaud N, et al. Mol Cell Biol, 1998 Jun. PMID 9584160, Free PMC Article
  4. Gene disruption and basic phenotypic analysis of nine novel yeast genes from chromosome XIV. Capozzo C, et al. Yeast, 2000 Sep 15. PMID 10953080
  5. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. Dumay-Odelot H, et al. J Biol Chem, 2007 Jun 8. PMID 17409385

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. tau55-HPD and Huf as bona fide protein phosphatases, characterize their substrate specificities, and provide a small set of regulated phosphosite targets in vivo.
    Title: Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
uncharacterized protein
NP_014291.1
  • Protein phosphatase; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    419014..419826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182946.1 → NP_014291.1  TPA: uncharacterized protein YNL108C [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014291.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W172, P53929
    UniProtKB/TrEMBL
    A6ZRX3, B3LNW6, C7GKD5, C8ZGC2, G2WLZ7, N1NXF9
    Conserved Domains (1) summary
    COG0406
    Location:5 → 227
    PhoE; Broad specificity phosphatase PhoE [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53929.1

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