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RAS2 Ras family GTPase RAS2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855625, updated on 3-Nov-2024

Summary

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Official Symbol
RAS2
Official Full Name
Ras family GTPase RAS2
Primary source
SGD:S000005042
Locus tag
YNL098C
See related
AllianceGenome:SGD:S000005042; FungiDB:YNL098C; VEuPathDB:YNL098C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CTN5; CYR3; GLC5; TSL7
Summary
Enables GTP binding activity and GTPase activity. Involved in several processes, including cytoplasm to vacuole targeting by the Cvt pathway; positive regulation of transcription by galactose; and protein localization to bud neck. Located in several cellular components, including endoplasmic reticulum membrane; mitochondrion; and nucleus. Used to study colorectal cancer. Human ortholog(s) of this gene implicated in Noonan syndrome 12 and colorectal cancer. Orthologous to human RRAS (RAS related) and RRAS2 (RAS related 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RAS2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (439602..440570, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Mic27p Neighboring gene putative tyrosine protein phosphatase OCA1 Neighboring gene Pls1p Neighboring gene Pho23p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Ras GDP/GTP cycle is regulated by oxidizing agents at the level of Ras regulators and effectors. Accorsi K, et al. FEBS Lett, 2001 Mar 9. PMID 11248252
  2. On ras gene function in yeast. Fraenkel DG. Proc Natl Acad Sci U S A, 1985 Jul. PMID 3895224, Free PMC Article
  3. A product of yeast RAS2 gene is a guanine nucleotide binding protein. Tamanoi F, et al. Proc Natl Acad Sci U S A, 1984 Nov. PMID 6438624, Free PMC Article
  4. Antibody mimicking the action of RAS proteins on yeast adenylyl cyclase: implication for RAS-effector interaction. Suzuki N, et al. Mol Cell Biol, 1993 Feb. PMID 7678694, Free PMC Article
  5. Ras membrane targeting is essential for glucose signaling but not for viability in yeast. Bhattacharya S, et al. Proc Natl Acad Sci U S A, 1995 Mar 28. PMID 7708760, Free PMC Article

See all (386) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function.
    Title: Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function.
  2. Active Ras2 in mitochondria promotes regulated cell death in a cAMP/PKA pathway-dependent manner in budding yeast.
    Title: Active Ras2 in mitochondria promotes regulated cell death in a cAMP/PKA pathway-dependent manner in budding yeast.
  3. Autophagy Stimulus-Dependent Role of the Small GTPase Ras2 in Peroxisome Degradation.
    Title: Autophagy Stimulus-Dependent Role of the Small GTPase Ras2 in Peroxisome Degradation.
  4. Fructose-1,6-bisphosphate is a potent activator of Ras2 in permeabilized yeast cells, likely acting through Cdc25.
    Title: Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras.
  5. Dominant negative Ras2 mutants survive lethal stressors following mild heat shock
    Title: Ras mutants enhance the ability of cells to anticipate future lethal stressors.
  6. These data show that deletion of any of Ras2, Tor1, or Sch9 proteins mimics calorie restriction and is sufficient to increase cell protection from oxydative stress.
    Title: Protection against cisplatin in calorie-restricted Saccharomyces cerevisiae is mediated by the nutrient-sensor proteins Ras2, Tor1, or Sch9 through its target glutathione.
  7. Rck1 promotes pseudohyphal growth by activating Ras2 and Kss1 in S. cerevisiae.
    Title: Rck1 up-regulates pseudohyphal growth by activating the Ras2 and MAP kinase pathways independently in Saccharomyces cerevisiae.
  8. Active Ras accumulates in internal membranes and mitochondria, both when cells are growing on glucose medium or are starved.
    Title: Live-cell imaging of endogenous Ras-GTP shows predominant Ras activation at the plasma membrane and in the nucleus in Saccharomyces cerevisiae.
  9. The Erf4 subunit of the yeast Ras palmitoyl acyltransferase is required for stability of the Acyl-Erf2 intermediate and palmitoyl transfer to a Ras2 substrate.
    Title: The Erf4 subunit of the yeast Ras palmitoyl acyltransferase is required for stability of the Acyl-Erf2 intermediate and palmitoyl transfer to a Ras2 substrate.
  10. RAS2 regulates spore formation via Ras/cyclic AMP/protein kinase A pathway.
    Title: Acetate regulation of spore formation is under the control of the Ras/cyclic AMP/protein kinase A pathway and carbon dioxide in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ascospore formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by galactose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to bud neck IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cytoplasmic mRNA processing body assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ras family GTPase RAS2
NP_014301.1
  • GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    439602..440570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182936.1 → NP_014301.1  TPA: Ras family GTPase RAS2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014301.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W181, P01120, Q45U01
    UniProtKB/TrEMBL
    A6ZRY2, B3LNV7, B5VQU4, C7GR80, C8ZGD1, G2WM06, N1NXG7
    Conserved Domains (1) summary
    smart00010
    Location:9 → 172
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01120.4

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