MKT1 Mkt1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MKT1
Official Full Name: Mkt1p
Primary source: SGD:S000005029
Locus tag: YNL085W
See related: AllianceGenome:SGD:S000005029; FungiDB:YNL085W; VEuPathDB:YNL085W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable DNA endonuclease activity and mRNA 3'-UTR binding activity. Involved in DNA damage response. Located in P-body and nuclear periphery. [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

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MKT1 alleles regulate stress responses through posttranscriptional modulation of Puf3 targets in budding yeast.
Title: MKT1 alleles regulate stress responses through posttranscriptional modulation of Puf3 targets in budding yeast.
A tps1Delta persister-like state in Saccharomyces cerevisiae is regulated by MKT1.
Title: A tps1Δ persister-like state in Saccharomyces cerevisiae is regulated by MKT1.
MKT1, SWS2, and APJ1 are associated with high ethanol tolerance in Saccharomyces cerevisiae.
Title: Identification of novel causative genes determining the complex trait of high ethanol tolerance in yeast using pooled-segregant whole-genome sequence analysis.
In a low-glucose environment, MDS3e and MKT1e interacted positively to confer a fitness advantage.
Title: Cellular effects and epistasis among three determinants of adaptation in experimental populations of Saccharomyces cerevisiae.
Studies show that by using CYS4 as a covariate and conducted both single- and combined-cross linkage mapping, AQY1 and MKT1 were found to have drug-specific and background-dependent effects.
Title: A combined-cross analysis reveals genes with drug-specific and background-dependent effects on drug sensitivity in Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed

NP_014314.3

Protein similar to nucleases that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress; localization to P-bodies under ethanol stress differs between strains

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