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NIS1 Nis1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855646, updated on 28-Oct-2024

Summary

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Official Symbol
NIS1
Official Full Name
Nis1p
Primary source
SGD:S000005022
Locus tag
YNL078W
See related
AllianceGenome:SGD:S000005022; FungiDB:YNL078W; VEuPathDB:YNL078W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
JIP1
Summary
Predicted to enable SUMO binding activity. Involved in axial cellular bud site selection; establishment of protein localization; and mitotic nuclear division. Located in cellular bud scar; cleavage apparatus septin structure; and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See NIS1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (479768..480991)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Eos1p Neighboring gene tropomyosin TPM1 Neighboring gene Apj1p Neighboring gene Mks1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast. Reiter A, et al. EMBO J, 2012 Aug 15. PMID 22805593, Free PMC Article
  2. Molecular evolution of minisatellites in hemiascomycetous yeasts. Richard GF, et al. Mol Biol Evol, 2006 Jan. PMID 16177231
  3. Fine-tuning the orientation of the polarity axis by Rga1, a Cdc42 GTPase-activating protein. Miller KE, et al. Mol Biol Cell, 2017 Dec 15. PMID 29074565, Free PMC Article
  4. The septin-associated kinase Gin4 recruits Gps1 to the site of cell division. Meitinger F, et al. Mol Biol Cell, 2017 Apr 1. PMID 28148650, Free PMC Article
  5. Nis1 encoded by YNL078W: a new neck protein of Saccharomyces cerevisiae. Iwase M, et al. Genes Genet Syst, 2001 Oct. PMID 11817649

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SUMO binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in axial cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic nuclear division IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck septin collar IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck split septin rings IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud scar IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Nis1p
NP_014321.3
  • Protein involved in axial bud site selection; prevents repolarization of cells at previous division sites; recruited with Nba1p to the cell cortex and to cytokinesis remnants (bud scars) by Aim44p and Nap1p where Nba1p prevents Rsr1p-mediated activation of Cdc24p, and therefore Cdc42p activation; acts with Nba1p to establish transient bud scar localization of Rga1p, a Cdc42p GAP; localizes to the nucleus and to cell division site during G2/M, and is then stably recruited to cytokinesis remnants

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    479768..480991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182916.3 → NP_014321.3  TPA: Nis1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014321.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1A1, P53939
    UniProtKB/TrEMBL
    B3LNT7, B5VQW5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53939.1

Gene LinkOut

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