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SFB2 COPII subunit SFB2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855678, updated on 2-Nov-2024

Summary

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Official Symbol
SFB2
Official Full Name
COPII subunit SFB2
Primary source
SGD:S000004994
Locus tag
YNL049C
See related
AllianceGenome:SGD:S000004994; FungiDB:YNL049C; VEuPathDB:YNL049C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ISS1
Summary
Predicted to enable SNARE binding activity; signal sequence binding activity; and zinc ion binding activity. Involved in COPII-coated vesicle cargo loading. Part of COPII vesicle coat. Orthologous to several human genes including SEC24A (SEC24 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SFB2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (535281..537911, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Golgi transport complex subunit COG5 Neighboring gene uncharacterized protein Neighboring gene alpha-1,2-mannosyltransferase ALG11 Neighboring gene phosphatidylinositol 4,5-bisphosphate-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The early secretory pathway contributes to autophagy in yeast. Hamasaki M, et al. Cell Struct Funct, 2003 Feb. PMID 12655150
  2. Endoplasmic reticulum exit of a secretory glycoprotein in the absence of sec24p family proteins in yeast. Karhinen L, et al. Traffic, 2005 Jul. PMID 15941408
  3. Sfb2p, a yeast protein related to Sec24p, can function as a constituent of COPII coats required for vesicle budding from the endoplasmic reticulum. Higashio H, et al. J Biol Chem, 2000 Jun 9. PMID 10749860
  4. ER-Golgi transport defects are associated with mutations in the Sed5p-binding domain of the COPII coat subunit, Sec24p. Miller EA, et al. Mol Biol Cell, 2005 Aug. PMID 15930124, Free PMC Article
  5. Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat. Kung LF, et al. EMBO J, 2012 Feb 15. PMID 22157747, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signal sequence binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in COPII-coated vesicle cargo loading IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in COPII-coated vesicle cargo loading IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat IEA
Inferred from Electronic Annotation
more info
  
part_of COPII vesicle coat IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
COPII subunit SFB2
NP_014349.1
  • Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SFB2 has a paralog, SEC24, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    535281..537911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182888.1 → NP_014349.1  TPA: COPII subunit SFB2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014349.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1D0, P53953
    UniProtKB/TrEMBL
    B3LNR0, B5VQZ1, C7GLV1
    Conserved Domains (1) summary
    COG5028
    Location:1 → 876
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53953.1

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