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EFM6 putative protein-lysine N-methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855707, updated on 28-Oct-2024

Summary

Official Symbol
EFM6
Official Full Name
putative protein-lysine N-methyltransferase
Primary source
SGD:S000004969
Locus tag
YNL024C
See related
AllianceGenome:SGD:S000004969; FungiDB:YNL024C; VEuPathDB:YNL024C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable S-adenosylmethionine-dependent methyltransferase activity and protein methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Located in cytoplasm. Orthologous to several human genes including METTL21A (methyltransferase 21A, HSPA lysine) and VCPKMT (valosin containing protein lysine methyltransferase). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

See EFM6 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (587107..587847, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ksh1p Neighboring gene Fap1p Neighboring gene rRNA (cytosine-C5-)-methyltransferase RCM1

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables S-adenosylmethionine-dependent methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-lysine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-lysine methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative protein-lysine N-methyltransferase
NP_014374.1
  • Putative S-adenosylmethionine-dependent lysine methyltransferase; responsible for modifying Lys-390 in translational elongation factor EF-1 alpha (eEF1A); has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    587107..587847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182863.1NP_014374.1  TPA: putative protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014374.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1F5, P53970
    UniProtKB/TrEMBL
    A6ZS50, B3LNP1, B5VR13, C7GWP1, C8ZFK0, G2WM75, N1NY28
    Conserved Domains (1) summary
    pfam10294
    Location:33218
    Methyltransf_16; Lysine methyltransferase