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RCM1 rRNA (cytosine-C5-)-methyltransferase RCM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855709, updated on 28-Oct-2024

Summary

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Official Symbol
RCM1
Official Full Name
rRNA (cytosine-C5-)-methyltransferase RCM1
Primary source
SGD:S000004967
Locus tag
YNL022C
See related
AllianceGenome:SGD:S000004967; FungiDB:YNL022C; VEuPathDB:YNL022C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables rRNA (cytosine-C5-)-methyltransferase activity. Involved in rRNA base methylation. Located in nucleolus. Orthologous to several human genes including NSUN5 (NOP2/Sun RNA methyltransferase 5). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See RCM1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (591427..592899, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative protein-lysine N-methyltransferase Neighboring gene Fap1p Neighboring gene histone deacetylase HDA1 Neighboring gene serine/threonine protein kinase ARK1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA. Kalhor HR, et al. Biochem Biophys Res Commun, 2005 Aug 26. PMID 16005430
  2. A cluster of methylations in the domain IV of 25S rRNA is required for ribosome stability. Gigova A, et al. RNA, 2014 Oct. PMID 25125595, Free PMC Article
  3. Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Schosserer M, et al. Nat Commun, 2015 Jan 30. PMID 25635753, Free PMC Article
  4. Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120. Bourgeois G, et al. PLoS One, 2015. PMID 26196125, Free PMC Article
  5. Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively. Sharma S, et al. Nucleic Acids Res, 2013 Oct. PMID 23913415, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rcm1 catalyzes methylation of m5C2278 of 25S rRNA in vivo.
    Title: Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (cytosine-C5-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA (cytosine-C5-)-methyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables rRNA (cytosine-C5-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA base methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA base methylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in rRNA base methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rRNA (cytosine-C5-)-methyltransferase RCM1
NP_014376.3
  • rRNA m5C methyltransferase; methylates cytosine at position 2278 of 25S rRNA while Nop2p methylates cytosine at position 2870; contains seven beta-strand methyltransferase motif; localized to the nucleolus; interacts with Trm112p; homolog of NSUN5A, a human gene which is deleted in Williams-Beuren Syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    591427..592899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182861.3 → NP_014376.3  TPA: rRNA (cytosine-C5-)-methyltransferase RCM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014376.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1F7, P53972
    UniProtKB/TrEMBL
    A6ZS48, B3LNP3, B5VR15, C7GWN9, C8ZFJ8, G2WM73, N1NXN1
    Conserved Domains (1) summary
    COG0144
    Location:98 → 489
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53972.1

Gene LinkOut

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