HRB1 mRNA-binding protein [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: HRB1
Official Full Name: mRNA-binding protein
Primary source: SGD:S000004949
Locus tag: YNL004W
See related: AllianceGenome:SGD:S000004949; FungiDB:YNL004W; VEuPathDB:YNL004W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TOM34
Summary: Enables chromatin binding activity and mRNA binding activity. Involved in nuclear mRNA surveillance. Located in cytoplasm and nucleus. Orthologous to human MYEF2 (myelin expression factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Nuclear SR-protein mediated mRNA quality control is continued in cytoplasmic nonsense-mediated decay.
Title: Nuclear SR-protein mediated mRNA quality control is continued in cytoplasmic nonsense-mediated decay.
Npl3p, Gbp2p, and Hrb1p are part of the S. cerevisiae translating mRNPs, and Npl3p is regulated by Mtr10p and can function as a translational repressor
Title: Yeast shuttling SR proteins Npl3p, Gbp2p, and Hrb1p are part of the translating mRNPs, and Npl3p can function as a translational repressor.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	HDA more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in nuclear mRNA surveillance	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear mRNA surveillance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_014394.2

Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain