CIT1 citrate (Si)-synthase CIT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CIT1
Official Full Name: citrate (Si)-synthase CIT1
Primary source: SGD:S000005284
Locus tag: YNR001C
See related: AllianceGenome:SGD:S000005284; FungiDB:YNR001C; VEuPathDB:YNR001C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LYS6
Summary: Enables citrate (Si)-synthase activity. Involved in acetyl-CoA catabolic process and citrate metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See CIT1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (629622..631061, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutathione (GSH) deficiency in cit1 null cells is caused by an insufficient supply of glutamate necessary for biosynthesis of GSH rather than the depletion of reducing power required for reduction of glutathione disulfide to GSH.
Title: Yeast cells lacking the CIT1-encoded mitochondrial citrate synthase are hypersusceptible to heat- or aging-induced apoptosis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables citrate (Si)-synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables citrate (Si)-synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables citrate (Si)-synthase activity	IEA Inferred from Electronic Annotation more info
enables citrate (Si)-synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables citrate synthase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acetyl-CoA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in citrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in citrate metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: citrate (Si)-synthase CIT1

NP_014398.1

EC 2.3.3.1

Mitochondrial citrate synthase; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate, which is the first and rate-limiting step of the TCA cycle; transcription subject to glucose repression; CIT1 has a paralog, CIT2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

629622..631061 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183178.1 → NP_014398.1 TPA: citrate (Si)-synthase CIT1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014398.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1H7, P00890

UniProtKB/TrEMBL

A6ZS76, B3LPN8, C7GJD9, C8ZFM6, G2WL59, N1NWR7

Conserved Domains (1) summary

cd06105
Location:45 → 471

ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...