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CSE2 Cse2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855744, updated on 18-Sep-2024

Summary

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Official Symbol
CSE2
Official Full Name
Cse2p
Primary source
SGD:S000005293
Locus tag
YNR010W
See related
AllianceGenome:SGD:S000005293; FungiDB:YNR010W; VEuPathDB:YNR010W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MED9
Summary
Enables structural molecule activity and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Part of core mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CSE2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (643744..644193)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene phospholipid:diacylglycerol acyltransferase Neighboring gene Nrm1p Neighboring gene DEAH-box RNA-dependent ATPase PRP2 Neighboring gene uridine kinase URK1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional interaction between the CSE2 gene product and centromeres in Saccharomyces cerevisiae. Xiao ZX, et al. J Mol Biol, 1995 Apr 28. PMID 7739039
  2. CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae. Xiao Z, et al. Mol Cell Biol, 1993 Aug. PMID 8336709, Free PMC Article
  3. SCM2, a tryptophan permease in Saccharomyces cerevisiae, is important for cell growth. Chen XH, et al. Mol Gen Genet, 1994 Aug 2. PMID 8058037
  4. Twelve open reading frames revealed in the 23.6 kb segment flanking the centromere on the Saccharomyces cerevisiae chromosome XIV right arm. Verhasselt P, et al. Yeast, 1994 Oct. PMID 7900425
  5. Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. Gustafsson CM, et al. J Biol Chem, 1998 Nov 20. PMID 9812975

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural molecule activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cse2p
NP_014407.3
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    643744..644193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183187.3 → NP_014407.3  TPA: Cse2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014407.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1I5, P33308
    UniProtKB/TrEMBL
    A6ZS84, B5VR41, C7GLP5, C8ZFN7, G2WL67, N1NWS4
    Conserved Domains (1) summary
    pfam07544
    Location:64 → 143
    Med9; RNA polymerase II transcription mediator complex subunit 9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33308.1

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