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ZNG1 GTP-dependent zinc transferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855763, updated on 2-Nov-2024

Summary

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Official Symbol
ZNG1
Official Full Name
GTP-dependent zinc transferase
Primary source
SGD:S000005312
Locus tag
YNR029C
See related
AllianceGenome:SGD:S000005312; FungiDB:YNR029C; VEuPathDB:YNR029C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity; enzyme activator activity; and zinc chaperone activity. Involved in cellular response to zinc ion starvation and protein maturation. Located in cytoplasm. Orthologous to several human genes including ZNG1A (Zn regulated GTPase metalloprotein activator 1A); ZNG1B (Zn regulated GTPase metalloprotein activator 1B); and ZNG1C (Zn regulated GTPase metalloprotein activator 1C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ZNG1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (677199..678488, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative pyridoxal kinase BUD17 Neighboring gene peptidylprolyl isomerase family protein CPR8 Neighboring gene dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase Neighboring gene mitogen-activated protein kinase kinase kinase SSK2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-resolution yeast phenomics resolves different physiological features in the saline response. Warringer J, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14676322, Free PMC Article
  2. Zng1 is a GTP-dependent zinc transferase needed for activation of methionine aminopeptidase. Pasquini M, et al. Cell Rep, 2022 May 17. PMID 35584675
  3. Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. Logan MR, et al. BMC Genomics, 2008 Jul 15. PMID 18627629, Free PMC Article
  4. Sulfate assimilation mediates tellurite reduction and toxicity in Saccharomyces cerevisiae. Ottosson LG, et al. Eukaryot Cell, 2010 Oct. PMID 20675578, Free PMC Article
  5. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Philippsen P, et al. Nature, 1997 May 29. PMID 9169873

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc chaperone activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to zinc ion starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to zinc ion starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein maturation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GTP-dependent zinc transferase
NP_014426.3
  • GTP-dependent zinc transferase; couples GTP hydrolysis to the activation of methionine aminopeptidase Map1p, especially during zinc starvation; deletion confers reduced fitness in saline; contains GTPase sequence motifs and a CxCC metal-binding motif

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    677199..678488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183206.3 → NP_014426.3  TPA: GTP-dependent zinc transferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014426.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1K3, P53729
    UniProtKB/TrEMBL
    A6ZSA2, B3LPL5, B5VR59, C7GLM9, C8ZFQ6, G2WL85, N1NWT7
    Conserved Domains (1) summary
    COG0523
    Location:71 → 428
    YejR; GTPase, G3E family [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53729.1

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