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VIK1 Vik1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855822, updated on 2-Nov-2024

Summary

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Official Symbol
VIK1
Official Full Name
Vik1p
Primary source
SGD:S000006174
Locus tag
YPL253C
See related
AllianceGenome:SGD:S000006174; FungiDB:YPL253C; VEuPathDB:YPL253C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables microtubule binding activity. Involved in microtubule-based process and mitotic sister chromatid cohesion. Acts upstream of or within microtubule nucleation. Located in spindle pole body. Part of kinesin complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VIK1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (71063..73006, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Bbp1p Neighboring gene Hfi1p Neighboring gene adrenodoxin Neighboring gene Atg41p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neck rotation and neck mimic docking in the noncatalytic Kar3-associated protein Vik1. Duan D, et al. J Biol Chem, 2012 Nov 23. PMID 23043140, Free PMC Article
  2. Cryo-electron tomography of microtubule-kinesin motor complexes. Cope J, et al. J Struct Biol, 2010 May. PMID 20025975, Free PMC Article
  3. Vik1 modulates microtubule-Kar3 interactions through a motor domain that lacks an active site. Allingham JS, et al. Cell, 2007 Mar 23. PMID 17382884, Free PMC Article
  4. The Kar3-interacting protein Cik1p plays a critical role in passage through meiosis I in Saccharomyces cerevisiae. Shanks RM, et al. Genetics, 2001 Nov. PMID 11729143, Free PMC Article
  5. The ATPase pathway that drives the kinesin-14 Kar3Vik1 powerstroke. Chen CJ, et al. J Biol Chem, 2012 Oct 26. PMID 22977241, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neck rotation and neck mimic docking in Vik1 and Cik1 is a structural mechanism for communication with Kar3.
    Title: Neck rotation and neck mimic docking in the noncatalytic Kar3-associated protein Vik1.
  2. Rapid ATP binding to Kar3 is associated with rotation of the coiled-coil stalk, and the postpowerstroke ATP hydrolysis is independent of Vik1.
    Title: The ATPase pathway that drives the kinesin-14 Kar3Vik1 powerstroke.
  3. show through structural determination of a C-terminal heterodimeric Kar3Vik1, electron microscopy, equilibrium binding, and motility that at the start of the cycle, Kar3Vik1 binds to or occludes two alphabeta-tubulin subunits on adjacent protofilaments
    Title: Kar3Vik1, a member of the kinesin-14 superfamily, shows a novel kinesin microtubule binding pattern.
  4. Vik1 binds more tightly to microtubules than Kar3 and facilitates cooperative microtubule decoration by Kar3/Vik1 heterodimers, and yet allows motility.
    Title: Vik1 modulates microtubule-Kar3 interactions through a motor domain that lacks an active site.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based process IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole body IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vik1p
NP_015070.1
  • Protein that forms a kinesin-14 heterodimeric motor with Kar3p; localizes Kar3p at mitotic spindle poles; has a structure similar to a kinesin motor domain but lacks an ATP-binding site and is catalytically inactive; binds microtubules; required for sister chromatid cohesion; VIK1 has a paralog, CIK1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    71063..73006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184067.1 → NP_015070.1  TPA: Vik1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015070.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3B8, Q12045, Q7LGU6
    UniProtKB/TrEMBL
    A6ZW03, C7GTR0, N1NVH9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12045.1

Gene LinkOut

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