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ATG41 Atg41p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855825, updated on 2-Nov-2024

Summary

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Official Symbol
ATG41
Official Full Name
Atg41p
Primary source
SGD:S000006171
Locus tag
YPL250C
See related
AllianceGenome:SGD:S000006171; FungiDB:YPL250C; VEuPathDB:YPL250C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ICY2
Summary
Involved in several processes, including autophagosome assembly; cellular response to nitrogen starvation; and cytoplasm to vacuole targeting by the Cvt pathway. Predicted to be located in phagophore assembly site membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ATG41 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (74309..74719, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Vik1p Neighboring gene adrenodoxin Neighboring gene ribosomal 60S subunit protein L36B Neighboring gene GTPase-activating protein GYP5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae. Arava Y, et al. Proc Natl Acad Sci U S A, 2003 Apr 1. PMID 12660367, Free PMC Article
  2. Lawsone, a 2-hydroxy-1,4-naphthoquinone from Lawsonia inermis (henna), produces mitochondrial dysfunctions and triggers mitophagy in Saccharomyces cerevisiae. Xavier MR, et al. Mol Biol Rep, 2020 Feb. PMID 31811499
  3. Global and specific translational regulation in the genomic response of Saccharomyces cerevisiae to a rapid transfer from a fermentable to a nonfermentable carbon source. Kuhn KM, et al. Mol Cell Biol, 2001 Feb. PMID 11154278, Free PMC Article
  4. Atg41/Icy2 regulates autophagosome formation. Yao Z, et al. Autophagy, 2015. PMID 26565778, Free PMC Article
  5. An Autophagy-Independent Role for ATG41 in Sulfur Metabolism During Zinc Deficiency. Bucci MD, et al. Genetics, 2018 Mar. PMID 29321173, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to nitrogen starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Atg41p
NP_015073.1
  • hypothetical protein; required for selective and nonselective autophagy, and mitophagy; regulates the rate of autophagosome formation; interacts with Atg9p, and has a similar peri-mitochondrial localization; elevated Gcn4p-dependent expression under autophagy-inducing conditions; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate; ATG41 has a paralog, ICY1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    74309..74719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184064.1 → NP_015073.1  TPA: Atg41p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015073.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3C0, Q12048
    UniProtKB/TrEMBL
    B3LKI1, C7GTQ8, C8ZIC8, G2WNT4, N1NW53
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12048.1

Gene LinkOut

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