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HUT1 UDP-galactose transporter HUT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855832, updated on 2-Nov-2024

Summary

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Official Symbol
HUT1
Official Full Name
UDP-galactose transporter HUT1
Primary source
SGD:S000006165
Locus tag
YPL244C
See related
AllianceGenome:SGD:S000006165; FungiDB:YPL244C; VEuPathDB:YPL244C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable UDP-galactose transmembrane transporter activity and UDP-glucose transmembrane transporter activity. Involved in UDP-galactose transmembrane transport and UDP-glucose transmembrane transport. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 26. Orthologous to several human genes including SLC35B1 (solute carrier family 35 member B1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HUT1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (87014..88033, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative rhomboid protease RBD2 Neighboring gene uncharacterized protein Neighboring gene signal recognition particle subunit SRP68 Neighboring gene Iqg1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of HUT1 gene stimulates in vivo galactosylation by enhancing UDP-galactose transport activity in Saccharomyces cerevisiae. Kainuma M, et al. Yeast, 2001 Apr. PMID 11284009
  2. Hut1 proteins identified in Saccharomyces cerevisiae and Schizosaccharomyces pombe are functional homologues involved in the protein-folding process at the endoplasmic reticulum. Nakanishi H, et al. Yeast, 2001 Apr. PMID 11284010
  3. Similarities between UDP-glucose and adenine nucleotide release in yeast: involvement of the secretory pathway. Esther CR Jr, et al. Biochemistry, 2008 Sep 2. PMID 18693752, Free PMC Article
  4. Loss of Cardiolipin Leads to Perturbation of Acetyl-CoA Synthesis. Raja V, et al. J Biol Chem, 2017 Jan 20. PMID 27941023, Free PMC Article
  5. Comprehensive and quantitative mapping of RNA-protein interactions across a transcribed eukaryotic genome. She R, et al. Proc Natl Acad Sci U S A, 2017 Apr 4. PMID 28325876, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables UDP-galactose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-galactose transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables UDP-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in UDP-galactose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-galactose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UDP-glucose transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in UDP-glucose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-galactose transporter HUT1
NP_015080.1
  • Protein with a role in UDP-galactose transport to the Golgi lumen; has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    87014..88033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184058.1 → NP_015080.1  TPA: UDP-galactose transporter HUT1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015080.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3C7, Q12520
    UniProtKB/TrEMBL
    A6ZW12, B3LKI8, B5VSU0, C7GTQ1, C8ZID5, N1NVK1
    Conserved Domains (1) summary
    pfam08449
    Location:7 → 321
    UAA; UAA transporter family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12520.1

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