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FAS2 trifunctional fatty acid synthase subunit FAS2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855845, updated on 2-Nov-2024

Summary

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Official Symbol
FAS2
Official Full Name
trifunctional fatty acid synthase subunit FAS2
Primary source
SGD:S000006152
Locus tag
YPL231W
See related
AllianceGenome:SGD:S000006152; FungiDB:YPL231W; VEuPathDB:YPL231W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; and holo-[acyl-carrier-protein] synthase activity. Contributes to fatty acid synthase activity. Involved in long-chain fatty acid biosynthetic process. Located in cytosol. Part of fatty acid synthase complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FAS2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (108652..114315)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene MIND complex subunit NSL1 Neighboring gene syntaxin Neighboring gene Usv1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A downstream regulatory element located within the coding sequence mediates autoregulated expression of the yeast fatty acid synthase gene FAS2 by the FAS1 gene product. Wenz P, et al. Nucleic Acids Res, 2001 Nov 15. PMID 11713312, Free PMC Article
  2. A mass spectrometry-based high-throughput screening method for engineering fatty acid synthases with improved production of medium-chain fatty acids. Xue P, et al. Biotechnol Bioeng, 2020 Jul. PMID 32219854
  3. Molecular cloning of fatty acid synthetase genes from Saccharomyces cerevisiae. Kuziora MA, et al. J Biol Chem, 1983 Oct 10. PMID 6311818
  4. Pantetheine-free mutants of the yeast fatty-acid-synthetase complex. Schweizer E, et al. Eur J Biochem, 1973 Nov 15. PMID 4590449
  5. The construction and application of diploid sake yeast with a homozygous mutation in the FAS2 gene. Kotaka A, et al. J Biosci Bioeng, 2010 Dec. PMID 20708434

See all (167) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genotypic analysis of the FAS2-F1279Y (3836T>A) polymorphism conferring high ethyl caprylate productivity in industrial sake yeast strains.
    Title: Genotypic analysis of the FAS2-F1279Y (3836T>A) polymorphism conferring high ethyl caprylate productivity in industrial sake yeast strains.
  2. Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS).
    Title: Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS).
  3. FAS2 molecular structure shows how acyl chain interacts with the hydrophobic cavity and gives it stability.
    Title: Interactions of the acyl chain with the Saccharomyces cerevisiae acyl carrier protein.
  4. The major ubiquitin ligase targeting the superfluous Fas2 subunit to the proteasome is Ubr1. The ubiquitin-conjugating enzymes Ubc2 and Ubc4 assist the degradation process.
    Title: Quality control of a cytoplasmic protein complex: chaperone motors and the ubiquitin-proteasome system govern the fate of orphan fatty acid synthase subunit Fas2 of yeast.
  5. Overexpression of FAS1, FAS2 and Acc1 leads to accumulation of sterols.
    Title: Overexpression of genes of the fatty acid biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables fatty acid synthase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to fatty acid synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables fatty-acyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables holo-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables holo-[acyl-carrier-protein] synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of fatty acid synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of fatty acid synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of fatty acid synthase complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
trifunctional fatty acid synthase subunit FAS2
NP_015093.1
  • Alpha subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    108652..114315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184045.1 → NP_015093.1  TPA: trifunctional fatty acid synthase subunit FAS2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015093.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3D9, P19097, Q12533
    UniProtKB/TrEMBL
    A0A140KF01, G2WNV4, N1NWL3
    Conserved Domains (4) summary
    COG4982
    Location:93 → 1169
    FabG2; 3-oxoacyl-ACP reductase domain of yeast-type FAS1 [Lipid transport and metabolism]
    cd00828
    Location:1135 → 1655
    elong_cond_enzymes; "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as ...
    TIGR00556
    Location:1765 → 1886
    pantethn_trn; phosphopantetheine--protein transferase domain
    cl08282
    Location:4 → 85
    Acyl_transf_1; Acyl transferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19097.2

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