U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DIP5 dicarboxylic amino acid permease [ Saccharomyces cerevisiae S288C ]

Gene ID: 855863, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
DIP5
Official Full Name
dicarboxylic amino acid permease
Primary source
SGD:S000006186
Locus tag
YPL265W
See related
AllianceGenome:SGD:S000006186; FungiDB:YPL265W; VEuPathDB:YPL265W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dicarboxylic acid transmembrane transporter activity. Involved in amino acid transport. Located in fungal-type vacuole membrane and plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A14 (solute carrier family 7 member 14); and SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See DIP5 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (41043..42869)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Acm1p Neighboring gene putative dimethyladenosine transferase Neighboring gene uncharacterized protein Neighboring gene Kel3p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dip5p mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate in Saccharomyces cerevisiae. Regenberg B, et al. Curr Genet, 1998 Mar. PMID 9508791
  2. Uptake of the beta-lactam precursor alpha-aminoadipic acid in Penicillium chrysogenum is mediated by the acidic and the general amino acid permease. Trip H, et al. Appl Environ Microbiol, 2004 Aug. PMID 15294814, Free PMC Article
  3. Clearance of yeast prions by misfolded multi-transmembrane proteins. Arai C, et al. Biochimie, 2013 Jun. PMID 23384482
  4. Adaptability of the Saccharomyces cerevisiae yeasts to wine fermentation conditions relies on their strong ability to consume nitrogen. Brice C, et al. PLoS One, 2018. PMID 29432462, Free PMC Article
  5. Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae. Rong-Mullins X, et al. PLoS One, 2017. PMID 29155836, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sequence comparison between the target proteins, i.e., the plant EPSPS and the yeast orthologous protein Aro1, predicted that yeast would be resistant to glyphosate. However, the growth variation seen in the subset of yeast tested was not due to polymorphisms within Aro1, instead, it was caused by genetic variation in an ABC multiple drug transporter, Pdr5, and an amino acid permease, Dip5
    Title: Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae.
  2. Results indicate that the regulation of Dip5 endocytosis is accomplished by dynamic recruitment of Rsp5 via Aly2.
    Title: Endocytosis of the aspartic acid/glutamic acid transporter Dip5 is triggered by substrate-dependent recruitment of the Rsp5 ubiquitin ligase via the arrestin-like protein Aly2.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dicarboxylic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in dicarboxylic acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
dicarboxylic amino acid permease
NP_015058.1
  • Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    41043..42869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184079.1 → NP_015058.1  TPA: dicarboxylic amino acid permease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015058.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3A5, P53388
    UniProtKB/TrEMBL
    B3LKG8, B5VSS2, C7GSG5, G2WNS1, N1NVT7
    Conserved Domains (1) summary
    TIGR00913
    Location:83 → 566
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53388.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools