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ALG5 dolichyl-phosphate beta-glucosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855874, updated on 18-Sep-2024

Summary

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Official Symbol
ALG5
Official Full Name
dolichyl-phosphate beta-glucosyltransferase
Primary source
SGD:S000006148
Locus tag
YPL227C
See related
AllianceGenome:SGD:S000006148; FungiDB:YPL227C; VEuPathDB:YPL227C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dolichyl-phosphate beta-glucosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Located in endoplasmic reticulum membrane. Used to study congenital disorder of glycosylation type I. Orthologous to human ALG5 (ALG5 dolichyl-phosphate beta-glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ALG5 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (120163..121167, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene polynucleotide 5'-phosphatase Neighboring gene New1p Neighboring gene ribosome-associated Tef1p biogenesis chaperone CHP1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of the ALG5 locus encoding the UDP-glucose:dolichyl-phosphate glucosyltransferase from Saccharomyces cerevisiae. Heesen S, et al. Eur J Biochem, 1994 Aug 15. PMID 8076653
  2. Two yeast mutations in glucosylation steps of the asparagine glycosylation pathway. Runge KW, et al. J Biol Chem, 1984 Jan 10. PMID 6423630
  3. Evidence that the synthesis of glucosylphosphodolichol in yeast involves a 35-kDa membrane protein. Palamarczyk G, et al. Proc Natl Acad Sci U S A, 1990 Apr. PMID 2138781, Free PMC Article
  4. A genetic system based on split-ubiquitin for the analysis of interactions between membrane proteins in vivo. Stagljar I, et al. Proc Natl Acad Sci U S A, 1998 Apr 28. PMID 9560251, Free PMC Article
  5. A hypomorphic allele of the first N-glycosylation gene, ALG7, causes mitochondrial defects in yeast. Mendelsohn RD, et al. Biochim Biophys Acta, 2005 May 25. PMID 15794922

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dolichyl-phosphate beta-glucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dolichyl-phosphate beta-glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dolichyl-phosphate beta-glucosyltransferase
NP_015097.1
  • UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; human ortholog ALG5 can partially complement yeast alg5 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    120163..121167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184041.1 → NP_015097.1  TPA: dolichyl-phosphate beta-glucosyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015097.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3E3, P40350
    UniProtKB/TrEMBL
    C7GU66, G2WNV8, N1P2K3
    Conserved Domains (1) summary
    cd04188
    Location:77 → 302
    DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40350.1

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