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RTT10 Rtt10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855919, updated on 29-Jun-2024

Summary

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Gene symbol
RTT10
Gene description
Rtt10p
Primary source
FungiDB:YPL183C
Locus tag
YPL183C
See related
SGD:S000006104; AllianceGenome:SGD:S000006104; VEuPathDB:YPL183C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ERE2; TRM734
Summary
Involved in endocytic recycling and wobble position ribose methylation. Located in endosome. Orthologous to human WDR6 (WD repeat domain 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RTT10 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (199495..202536, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mrn1p Neighboring gene putative mitochondrial 54S ribosomal protein RTC6 Neighboring gene Cti6p Neighboring gene Tco89p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Different phosphoisoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner. Nemec CM, et al. Proc Natl Acad Sci U S A, 2017 May 16. PMID 28465432, Free PMC Article
  2. Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition. Hirata A, et al. Nucleic Acids Res, 2019 Nov 18. PMID 31586407, Free PMC Article
  3. The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development. Lardenois A, et al. Nucleic Acids Res, 2015 Jan. PMID 25477386, Free PMC Article
  4. Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Shi Y, et al. Mol Biol Cell, 2011 Nov. PMID 21880895, Free PMC Article
  5. Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis. Nyswaner KM, et al. Genetics, 2008 Jan. PMID 18202368, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
    Title: Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
  2. our data indicate that a complex containing the two novel proteins, Ere1 and Ere2, mediates cargo-specific recognition by the retromer pathway. [Ere2]
    Title: Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in wobble position ribose methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wobble position ribose methylation IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rtt10p
NP_015142.1
  • WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    199495..202536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183997.1 → NP_015142.1  TPA: Rtt10p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015142.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3I6, Q08924
    UniProtKB/TrEMBL
    A0A8H4BUL9, C7GJD1, C8ZIJ5, N1NWB0
    Conserved Domains (3) summary
    COG2319
    Location:175 → 525
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:224 → 261
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5 → 297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08924.1

Gene LinkOut

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