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TRE1 Tre1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855927, updated on 2-Nov-2024

Summary

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Official Symbol
TRE1
Official Full Name
Tre1p
Primary source
SGD:S000006097
Locus tag
YPL176C
See related
AllianceGenome:SGD:S000006097; FungiDB:YPL176C; VEuPathDB:YPL176C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable carboxypeptidase activity. Involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in fungal-type vacuole. Human ortholog(s) of this gene implicated in breast carcinoma; hemochromatosis (multiple); immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to several human genes including NAALADL1 (N-acetylated alpha-linked acidic dipeptidase like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TRE1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (216012..218363, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene nuclear cap-binding protein subunit CBC2 Neighboring gene Cup9p Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase SPT14 Neighboring gene Nip100p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transferrin receptor-like proteins control the degradation of a yeast metal transporter. Stimpson HE, et al. EMBO J, 2006 Feb 22. PMID 16456538, Free PMC Article
  2. Multiple interactions drive adaptor-mediated recruitment of the ubiquitin ligase rsp5 to membrane proteins in vivo and in vitro. Sullivan JA, et al. Mol Biol Cell, 2007 Jul. PMID 17429078, Free PMC Article
  3. Cell surface polarization during yeast mating. Bagnat M, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12374868, Free PMC Article
  4. Diversification at transcription factor binding sites within a species and the implications for environmental adaptation. Ames RM, et al. Mol Biol Evol, 2011 Dec. PMID 21693437
  5. Down-regulation of a manganese transporter in the face of metal toxicity. Jensen LT, et al. Mol Biol Cell, 2009 Jun. PMID 19369420, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tre1p
NP_015149.1
  • Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitination and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    216012..218363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183990.1 → NP_015149.1  TPA: Tre1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015149.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3J2, Q08919
    UniProtKB/TrEMBL
    B3LKQ2, B5VSZ5, C7GJC5, C8ZIK2, N1NVP0
    Conserved Domains (3) summary
    cl28883
    Location:221 → 374
    PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
    cd03874
    Location:402 → 617
    M28_PMSA_TfR_like; M28 Zn-peptidase Transferrin Receptor-like family
    pfam04253
    Location:642 → 769
    TFR_dimer; Transferrin receptor-like dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08919.1

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