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OYE3 NADPH dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855932, updated on 2-Nov-2024

Summary

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Official Symbol
OYE3
Official Full Name
NADPH dehydrogenase
Primary source
SGD:S000006092
Locus tag
YPL171C
See related
AllianceGenome:SGD:S000006092; FungiDB:YPL171C; VEuPathDB:YPL171C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ZRG6
Summary
Enables NADPH dehydrogenase activity. Involved in apoptotic process. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See OYE3 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (226169..227371, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL40 Neighboring gene protoheme IX farnesyltransferase Neighboring gene Dap1p Neighboring gene Mex67p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinetic studies of the old yellow enzyme. I. The reaction mechanism of the enzyme with reduced nicotinamide adenine dinucleotide. Honma T, et al. Biochim Biophys Acta, 1977 Sep 15. PMID 196654
  2. Engineering of Yeast Old Yellow Enzyme OYE3 Enables Its Capability Discriminating of (E)-Citral and (Z)-Citral. Wang T, et al. Molecules, 2021 Aug 20. PMID 34443627, Free PMC Article
  3. Candida albicans estrogen-binding protein gene encodes an oxidoreductase that is inhibited by estradiol. Madani ND, et al. Proc Natl Acad Sci U S A, 1994 Feb 1. PMID 8302868, Free PMC Article
  4. Ectopic expression of an Old Yellow Enzyme (OYE3) gene from Saccharomyces cerevisiae increases the tolerance and phytoremediation of 2-nitroaniline in rice. Li Z, et al. Gene, 2024 May 15. PMID 38325666
  5. Enhanced transformation of TNT by Arabidopsis plants expressing an old yellow enzyme. Zhu B, et al. PLoS One, 2012. PMID 22808068, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ectopic expression of an Old Yellow Enzyme (OYE3) gene from Saccharomyces cerevisiae increases the tolerance and phytoremediation of 2-nitroaniline in rice.
    Title: Ectopic expression of an Old Yellow Enzyme (OYE3) gene from Saccharomyces cerevisiae increases the tolerance and phytoremediation of 2-nitroaniline in rice.
  2. OYE proteins are firmly placed in the signaling network connecting ROS generation, PCD modulation, and cytoskeletal dynamics in yeast.
    Title: Old yellow enzymes, highly homologous FMN oxidoreductases with modulating roles in oxidative stress and programmed cell death in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables NADPH dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADPH dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADPH dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
NADPH dehydrogenase
NP_015154.1
  • Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    226169..227371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183985.1 → NP_015154.1  TPA: NADPH dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015154.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3J7, E9P937, P41816
    UniProtKB/TrEMBL
    A6ZW82, B3LKQ7, B5VT01, C7GJC2, C8ZIK7, N1P1D3
    Conserved Domains (1) summary
    cd02933
    Location:16 → 372
    OYE_like_FMN; Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41816.2

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