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ATG29 Atg29p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855937, updated on 17-May-2024

Summary

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Gene symbol
ATG29
Gene description
Atg29p
Primary source
FungiDB:YPL166W
Locus tag
YPL166W
See related
SGD:S000006087; AllianceGenome:SGD:S000006087; VEuPathDB:YPL166W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables SNARE binding activity. Involved in autophagy of mitochondrion; autophagy of nucleus; and protein localization to phagophore assembly site. Located in phagophore assembly site. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ATG29 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (237338..237979)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mrx4p Neighboring gene DNA-directed DNA polymerase Neighboring gene Set6p Neighboring gene mismatch repair protein MLH3 Neighboring gene Svs1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a novel autophagy-specific gene, ATG29. Kawamata T, et al. Biochem Biophys Res Commun, 2005 Dec 30. PMID 16289106
  2. Structural characterization of the Saccharomyces cerevisiae autophagy regulatory complex Atg17-Atg31-Atg29. Chew LH, et al. Autophagy, 2013 Oct. PMID 23939028, Free PMC Article
  3. Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae. Kabeya Y, et al. Biochem Biophys Res Commun, 2009 Nov 27. PMID 19755117
  4. Rab5-dependent autophagosome closure by ESCRT. Zhou F, et al. J Cell Biol, 2019 Jun 3. PMID 31010855, Free PMC Article
  5. Scaffolding the cup-shaped double membrane in autophagy. Bahrami AH, et al. PLoS Comput Biol, 2017 Oct. PMID 29065154, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atg17 adopts multiple conformations in the absence of Atg31 and Atg29 suggests that the two smaller components play key roles in defining and maintaining the distinct curvature of the ternary complex
    Title: Structural characterization of the Saccharomyces cerevisiae autophagy regulatory complex Atg17-Atg31-Atg29.
  2. single-particle electron microscopy analysis of the Atg17-Atg31-Atg29 complex reveals an elongated structure with Atg29 located at the opposing ends.
    Title: Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation.
  3. Atg17-Atg29-Atg31 ternary complex acts as a functional unit for autophagosome formation.
    Title: Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.
  4. it is proposed that Atg29 functions in autophagosome formation at the pre-autophagosomal structure in collaboration with other Atg proteins
    Title: Characterization of a novel autophagy-specific gene, ATG29.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNARE binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to nitrogen starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Atg29p
NP_015159.1
  • Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    237338..237979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183980.1 → NP_015159.1  TPA: Atg29p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015159.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3K2, Q12092
    UniProtKB/TrEMBL
    A0A8H4BUM8, C8ZIL2, N1P1D8
    Conserved Domains (1) summary
    pfam18388
    Location:8 → 63
    Atg29_N; Atg29 N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12092.1

Gene LinkOut

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