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SET6 Set6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855938, updated on 3-Nov-2024

Summary

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Official Symbol
SET6
Official Full Name
Set6p
Primary source
SGD:S000006086
Locus tag
YPL165C
See related
AllianceGenome:SGD:S000006086; FungiDB:YPL165C; VEuPathDB:YPL165C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable methyltransferase activity and zinc ion binding activity. Predicted to be involved in methylation. Predicted to be active in nucleus. Orthologous to several human genes including SMYD2 (SET and MYND domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SET6 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (237956..239077, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mrx4p Neighboring gene DNA-directed DNA polymerase Neighboring gene Atg29p Neighboring gene mismatch repair protein MLH3 Neighboring gene Svs1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Giaever G, et al. Proc Natl Acad Sci U S A, 2004 Jan 20. PMID 14718668, Free PMC Article
  2. FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p. Helliwell SB, et al. Nat Commun, 2015 Oct 12. PMID 26456460, Free PMC Article
  3. Evolution of SET-domain protein families in the unicellular and multicellular Ascomycota fungi. Veerappan CS, et al. BMC Evol Biol, 2008 Jul 1. PMID 18593478, Free PMC Article
  4. The Set2 methyltransferase associates with Ssn6 yet Tup1-Ssn6 repression is independent of histone methylation. Tripic T, et al. Biochem Biophys Res Commun, 2006 Jan 20. PMID 16329992
  5. Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2. Schibler A, et al. Genes Dev, 2016 May 15. PMID 27198228, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Set6p
NP_015160.1
  • SET domain hypothetical protein; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    237956..239077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183979.1 → NP_015160.1  TPA: Set6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015160.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3K3, Q12529
    UniProtKB/TrEMBL
    B5VT05, C7GJB7
    Conserved Domains (1) summary
    COG2940
    Location:1 → 370
    SET; SET domain-containing protein (function unknown) [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12529.1

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