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RPL33A ribosomal 60S subunit protein L33A [ Saccharomyces cerevisiae S288C ]

Gene ID: 855960, updated on 18-Sep-2024

Summary

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Official Symbol
RPL33A
Official Full Name
ribosomal 60S subunit protein L33A
Primary source
SGD:S000006064
Locus tag
YPL143W
See related
AllianceGenome:SGD:S000006064; FungiDB:YPL143W; VEuPathDB:YPL143W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GCD17; RPL37A
Summary
A structural constituent of ribosome. Involved in cytoplasmic translation; rRNA processing; and ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Used to study Diamond-Blackfan anemia. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 5. Orthologous to human RPL35A (ribosomal protein L35a). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RPL33A in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
2
Sequence:
Chromosome: XVI; NC_001148.4 (282122..282970)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Poc4p Neighboring gene ncRNA Neighboring gene protein kinase FRK1 Neighboring gene putative mitogen-activated protein kinase kinase MKK2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct ribosome maturation defects in yeast models of Diamond-Blackfan anemia and Shwachman-Diamond syndrome. Moore JB 4th, et al. Haematologica, 2010 Jan. PMID 19713223, Free PMC Article
  2. Saccharomyces cerevisiae ribosomal protein L37 is encoded by duplicate genes that are differentially expressed. Tornow J, et al. Curr Genet, 1994 Jun. PMID 8082197
  3. Screening a yeast promoter library leads to the isolation of the RP29/L32 and SNR17B/RPL37A divergent promoters and the discovery of a gene encoding ribosomal protein L37. Santangelo GM, et al. Gene, 1991 Aug 30. PMID 1840541
  4. Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translation. Martín-Marcos P, et al. Mol Cell Biol, 2007 Sep. PMID 17548477, Free PMC Article
  5. A yeast chemical genetics approach identifies the compound 3,4,5-trimethoxybenzyl isothiocyanate as a calcineurin inhibitor. Prescott TA, et al. FEBS Lett, 2014 Jan 31. PMID 24374339

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 60S subunit protein L33A
NP_015182.1
  • Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    282122..282970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183957.1 → NP_015182.1  TPA: ribosomal 60S subunit protein L33A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015182.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3M6, P05744
    UniProtKB/TrEMBL
    A6ZWB1, C7GJ94, C8ZIN6, G2WP40, N1NVG1
    Conserved Domains (1) summary
    pfam01247
    Location:7 → 100
    Ribosomal_L35Ae; Ribosomal protein L35Ae
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05744.3

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