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FRK1 protein kinase FRK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855962, updated on 3-Nov-2024

Summary

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Official Symbol
FRK1
Official Full Name
protein kinase FRK1
Primary source
SGD:S000006062
Locus tag
YPL141C
See related
AllianceGenome:SGD:S000006062; FungiDB:YPL141C; VEuPathDB:YPL141C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein kinase activity. Acts upstream of or within peroxisome inheritance and vacuole inheritance. Located in cytoplasm. Human ortholog(s) of this gene implicated in anencephaly and uterine fibroid. Orthologous to human NUAK1 (NUAK family kinase 1) and NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FRK1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (283464..286061, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L33A Neighboring gene putative mitogen-activated protein kinase kinase MKK2 Neighboring gene Ume1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatiotemporal regulation of organelle transport by spindle position checkpoint kinase Kin4. Ekal L, et al. J Cell Sci, 2024 Sep 25. PMID 39318281
  2. Saccharomyces cerevisiae gene YMR291W/TDA1 mediates the in vivo phosphorylation of hexokinase isoenzyme 2 at serine-15. Kettner K, et al. FEBS Lett, 2012 Feb 17. PMID 22289182
  3. The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. D'Aquino KE, et al. Mol Cell, 2005 Jul 22. PMID 16039591
  4. Protein kinases are associated with multiple, distinct cytoplasmic granules in quiescent yeast cells. Shah KH, et al. Genetics, 2014 Dec. PMID 25342717, Free PMC Article
  5. Spindle Position Checkpoint Kinase Kin4 Regulates Organelle Transport in Saccharomyces cerevisiae. Ekal L, et al. Biomolecules, 2023 Jul 10. PMID 37509134, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peroxisome inheritance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vacuole inheritance IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein kinase FRK1
NP_015184.1
  • Protein kinase; minor role relative to Kin4p in regulating peroxisomal transport and vacuolar inheritance; protects the peroxisomal Myo2p receptor Inp2p from degradation in mother cells along with Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    283464..286061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183955.1 → NP_015184.1  TPA: protein kinase FRK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015184.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3M7, Q03002
    UniProtKB/TrEMBL
    A6ZWB2, B3LKT5, C7GJ93, C8ZIN8, N1P1G7
    Conserved Domains (1) summary
    cl21453
    Location:39 → 313
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03002.1

Gene LinkOut

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