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MKK2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855963, updated on 11-Sep-2024

Summary

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Official Symbol
MKK2
Primary source
SGD:S000006061
Locus tag
YPL140C
See related
AllianceGenome:SGD:S000006061; FungiDB:YPL140C; VEuPathDB:YPL140C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPI6; SSP33
Summary
Predicted to enable MAP kinase kinase activity. Involved in autophagy of peroxisome; cell wall integrity MAPK cascade; and regulation of fungal-type cell wall organization. Located in several cellular components, including cellular bud neck; cellular bud tip; and mating projection tip. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; cardiofaciocutaneous syndrome 4; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1) and MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (287514..289034, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L33A Neighboring gene protein kinase FRK1 Neighboring gene Ume1p Neighboring gene Spp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential Role of Threonine and Tyrosine Phosphorylation in the Activation and Activity of the Yeast MAPK Slt2. González-Rubio G, et al. Int J Mol Sci, 2021 Jan 23. PMID 33498635, Free PMC Article
  2. Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor. Rancati G, et al. Cell, 2008 Nov 28. PMID 19041751, Free PMC Article
  3. Retrophosphorylation of Mkk1 and Mkk2 MAPKKs by the Slt2 MAPK in the yeast cell integrity pathway. Jiménez-Sánchez M, et al. J Biol Chem, 2007 Oct 26. PMID 17711850
  4. A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicans. Navarro-García F, et al. Microbiology (Reading), 1998 Feb. PMID 9493378
  5. Coordination of the mating and cell integrity mitogen-activated protein kinase pathways in Saccharomyces cerevisiae. Buehrer BM, et al. Mol Cell Biol, 1997 Nov. PMID 9343415, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that that two alternative MAPKKs, Pbs2 and Mkk2, can be forced to functionally replace the mating MAPKK Ste7, but only if the proper set of recruitment interactions are grafted onto their catalytic domains.
    Title: Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase.
  2. Retrophosphorylation of MKK2 by the SLT2 MAPK in the yeast cell integrity pathway is reported.
    Title: Retrophosphorylation of Mkk1 and Mkk2 MAPKKs by the Slt2 MAPK in the yeast cell integrity pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall integrity MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell wall integrity MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pexophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of fungal-type cell wall organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative mitogen-activated protein kinase kinase MKK2
NP_015185.1
  • MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    287514..289034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183954.1 → NP_015185.1  TPA: putative mitogen-activated protein kinase kinase MKK2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015185.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3M8, P32491
    UniProtKB/TrEMBL
    A6ZWB3, B3LKT6, B5VT26, C7GJ92, C8ZIN9, G2WP42, N1NX19
    Conserved Domains (1) summary
    cd06621
    Location:212 → 499
    PKc_Pek1_like; Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32491.2

Gene LinkOut

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