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RNY1 ribonuclease T2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855980, updated on 2-Nov-2024

Summary

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Official Symbol
RNY1
Official Full Name
ribonuclease T2
Primary source
SGD:S000006044
Locus tag
YPL123C
See related
AllianceGenome:SGD:S000006044; FungiDB:YPL123C; VEuPathDB:YPL123C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA endonuclease activity. Involved in RNA catabolic process; apoptotic process; and cell morphogenesis. Acts upstream of or within mRNA catabolic process. Located in cytosol; extracellular region; and fungal-type vacuole. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; RNASET2-deficient cystic leukoencephalopathy; colorectal cancer (multiple); lung cancer; and mismatch repair cancer syndrome. Orthologous to human RNASET2 (ribonuclease T2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RNY1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (317641..318945, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Kap120p Neighboring gene Spc29p Neighboring gene TFIIH/NER complex subunit TFB2 Neighboring gene Mei5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure-function analysis of Rny1 in tRNA cleavage and growth inhibition. Luhtala N, et al. PLoS One, 2012. PMID 22829915, Free PMC Article
  2. Characterization of Rny1, the Saccharomyces cerevisiae member of the T2 RNase family of RNases: unexpected functions for ancient enzymes? MacIntosh GC, et al. Proc Natl Acad Sci U S A, 2001 Jan 30. PMID 11158587, Free PMC Article
  3. Golgi-mediated glycosylation determines residency of the T2 RNase Rny1p in Saccharomyces cerevisiae. Shcherbik N. Traffic, 2013 Dec. PMID 24102742
  4. Selectivity of mRNA degradation by autophagy in yeast. Makino S, et al. Nat Commun, 2021 Apr 19. PMID 33875662, Free PMC Article
  5. Widespread Co-translational RNA Decay Reveals Ribosome Dynamics. Pelechano V, et al. Cell, 2015 Jun 4. PMID 26046441, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glycosylation of N7, N70, N103 and N123 is critical for Rny1 extracellular secretion.
    Title: Golgi-mediated glycosylation determines residency of the T2 RNase Rny1p in Saccharomyces cerevisiae.
  2. Biochemical flotation assays reveal that in rny1Delta cells, some tRNA molecules associate with membranes suggesting that cleavage of tRNAs by Rny1 can involve either tRNA association with, or uptake into, membrane compartments.
    Title: Structure-function analysis of Rny1 in tRNA cleavage and growth inhibition.
  3. Rny1p is released from the vacuole into the cytosol and cleaves tRNAs during oxidative stress.
    Title: The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA endonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonuclease T2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar lumen IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribonuclease T2
NP_015202.1
  • Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; required for tRNA-specific translational pausing during oxidative stress; promotes apoptosis under stress conditions and this function is independent of Rny1p catalytic activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    317641..318945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183937.1 → NP_015202.1  TPA: ribonuclease T2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015202.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3P4, Q02933
    UniProtKB/TrEMBL
    B3LKV1, B5VT42, C7GJ77, C8ZIQ6, N1NVG5
    Conserved Domains (1) summary
    cd01061
    Location:50 → 284
    RNase_T2_euk; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02933.1

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