U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MEI5 Mei5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855982, updated on 29-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
MEI5
Gene description
Mei5p
Primary source
FungiDB:YPL121C
Locus tag
YPL121C
See related
SGD:S000006042; AllianceGenome:SGD:S000006042; VEuPathDB:YPL121C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPH6
Summary
Involved in meiotic DNA recombinase assembly and reciprocal meiotic recombination. Located in condensed nuclear chromosome. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MEI5 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (320962..321630, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribonuclease T2 Neighboring gene TFIIH/NER complex subunit TFB2 Neighboring gene beclin 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination. Sawant P, et al. Genes Genet Syst, 2023 Jun 23. PMID 37225456
  2. The budding yeast Mei5-Sae3 complex interacts with Rad51 and preferentially binds a DNA fork structure. Say AF, et al. DNA Repair (Amst), 2011 Jun 10. PMID 21543267, Free PMC Article
  3. The budding yeast mei5 and sae3 proteins act together with dmc1 during meiotic recombination. Tsubouchi H, et al. Genetics, 2004 Nov. PMID 15579681, Free PMC Article
  4. Control of relative timing and stoichiometry by a master regulator. Goldschmidt Y, et al. PLoS One, 2015. PMID 26000862, Free PMC Article
  5. Rad51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosis. Cloud V, et al. Science, 2012 Sep 7. PMID 22955832, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination.
    Title: The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination.
  2. show the Mei5-Sae3 complex preferentially binds a fork-like DNA substrate to 3' overhanging DNA, single-stranded DNA or double-stranded DNA
    Title: The budding yeast Mei5-Sae3 complex interacts with Rad51 and preferentially binds a DNA fork structure.
  3. Mei5-Sae3 is a mediator of Dmc1 assembly during meiotic recombination in S. cerevisiae.
    Title: The Mei5-Sae3 protein complex mediates Dmc1 activity in Saccharomyces cerevisiae.
  4. Mei5 and Sae3 are loading factors for the RecA homolog Dmc1 recombinase and the Dmc1-Mei5-Sae3 complex is integrated onto Rad51 ensembles and plays both catalytic and structural roles in interhomolog recombination during meiosis.
    Title: A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic DNA recombinase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Mei5p
NP_015204.1
  • Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    320962..321630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183935.1 → NP_015204.1  TPA: Mei5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015204.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3P6, P32489, Q02946
    UniProtKB/TrEMBL
    A0A6A5Q4Y7, A6ZWD1, B3LKV3, B5VT45, C7GJ75, C8ZIQ8, G2WP60, N1NW23
    Conserved Domains (1) summary
    pfam10376
    Location:15 → 222
    Mei5; Double-strand recombination repair protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32489.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools