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HOS3 histone deacetylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855987, updated on 28-Oct-2024

Summary

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Official Symbol
HOS3
Official Full Name
histone deacetylase
Primary source
SGD:S000006037
Locus tag
YPL116W
See related
AllianceGenome:SGD:S000006037; FungiDB:YPL116W; VEuPathDB:YPL116W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables histone deacetylase activity. Involved in G1/S transition of mitotic cell cycle and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including cellular bud neck; nucleus; and prospore membrane. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See HOS3 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (329606..331699)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein MRP51 Neighboring gene isopentenyl-diphosphate delta-isomerase IDI1 Neighboring gene GTPase-activating protein BEM3 Neighboring gene glyoxylate reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bypassing Sir2 and O-acetyl-ADP-ribose in transcriptional silencing. Chou CC, et al. Mol Cell, 2008 Sep 5. PMID 18775325, Free PMC Article
  2. Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity. Carmen AA, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10535926, Free PMC Article
  3. Structural characterization of fungus-specific histone deacetylase Hos3 provides insights into developing selective inhibitors with antifungal activity. Pang N, et al. J Biol Chem, 2022 Jul. PMID 35623387, Free PMC Article
  4. Polyamines inhibit the yeast histone deacetylase. Vu QA, et al. FEBS Lett, 1987 Aug 10. PMID 3301411
  5. Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10. Ahn SH, et al. Mol Cell, 2006 Oct 20. PMID 17052455

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in G1/S transition of mitotic cell cycle IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in prospore membrane HDA PubMed 

General protein information

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Preferred Names
histone deacetylase
NP_015209.1
  • Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    329606..331699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183930.1 → NP_015209.1  TPA: histone deacetylase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015209.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Q2, Q02959
    UniProtKB/TrEMBL
    A6ZWD6, B3LKV8, B5VT50, C7GJ69, C8ZIR4, G2WP66, N1NX39
    Conserved Domains (1) summary
    cd09998
    Location:47 → 435
    HDAC_Hos3; Class II histone deacetylases Hos3 and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02959.1

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