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MGR2 Mgr2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856006, updated on 1-Aug-2024

Summary

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Gene symbol
MGR2
Gene description
Mgr2p
Primary source
FungiDB:YPL098C
Locus tag
YPL098C
See related
SGD:S000006019; AllianceGenome:SGD:S000006019; VEuPathDB:YPL098C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein import into mitochondrial matrix and protein insertion into mitochondrial inner membrane. Located in mitochondrion. Part of TIM23 mitochondrial import inner membrane translocase complex. Orthologous to human ROMO1 (reactive oxygen species modulator 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MGR2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (364386..364727, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Atg21p Neighboring gene Ina17p Neighboring gene tyrosine--tRNA ligase MSY1 Neighboring gene Eri1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deletion of Mgr2p Affects the Gating Behavior of the TIM23 Complex. Mirzalieva O, et al. Front Physiol, 2018. PMID 30697167, Free PMC Article
  2. The Mgr2 subunit of the TIM23 complex regulates membrane insertion of marginal stop-transfer signals in the mitochondrial inner membrane. Lee S, et al. FEBS Lett, 2020 Mar. PMID 31764998
  3. Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence. Ieva R, et al. Nat Commun, 2013. PMID 24287567
  4. Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane. Ieva R, et al. Mol Cell, 2014 Dec 4. PMID 25454944
  5. A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex. Dunn CD, et al. Mol Biol Cell, 2006 Jan. PMID 16267274, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Mgr2 subunit of the TIM23 complex regulates membrane insertion of marginal stop-transfer signals in the mitochondrial inner membrane.
    Title: The Mgr2 subunit of the TIM23 complex regulates membrane insertion of marginal stop-transfer signals in the mitochondrial inner membrane.
  2. Data propose that Mgr2 functions at the checkpoint for lateral sorting of the TIM23 complex in mitochondria.
    Title: Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane.
  3. Removal of the Mgr2 C-terminal targeting signal by Imp1 is required for TIM23 complex assembly and function.
    Title: Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence.
  4. The Mgr2 is a coupling factor of the presequence translocase crucial for cell growth at elevated temperature and for efficient protein import.
    Title: Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into mitochondrial matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein insertion into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TIM23 mitochondrial import inner membrane translocase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
Mgr2p
NP_015227.1
  • Core component of the TIM23 protein translocase complex; couples Tim21 with the core Tim23 translocase; provides quality control for membrane protein insertion, regulating their release into the inner membrane by the TIM23 complex; required for mitochondrial import of presequence-containing proteins at elevated temperature; forms the translocation path with Tim17p, sealing the lateral opening of the Tim17p cavity; required for viability of cells lacking the mitochondrial genome (petite-negative)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    364386..364727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183912.1 → NP_015227.1  TPA: Mgr2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015227.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3R8, Q02889
    UniProtKB/TrEMBL
    A6ZWF2, B3LKX4, C7GJ53, C8ZIT2, G2WP82, N1NVH0
    Conserved Domains (1) summary
    pfam10247
    Location:14 → 79
    Romo1; Reactive mitochondrial oxygen species modulator 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02889.1

Gene LinkOut

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