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EEB1 medium-chain fatty acid ethyl ester synthase/esterase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856010, updated on 18-Sep-2024

Summary

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Official Symbol
EEB1
Official Full Name
medium-chain fatty acid ethyl ester synthase/esterase
Primary source
SGD:S000006016
Locus tag
YPL095C
See related
AllianceGenome:SGD:S000006016; FungiDB:YPL095C; VEuPathDB:YPL095C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alcohol O-octanoyltransferase activity and short-chain carboxylesterase activity. Involved in medium-chain fatty acid biosynthetic process and medium-chain fatty acid catabolic process. Orthologous to human ABHD1 (abhydrolase domain containing 1) and ABHD3 (abhydrolase domain containing 3, phospholipase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EEB1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (368071..369441, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Eri1p Neighboring gene peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase Neighboring gene Sec63 complex subunit SEC62 Neighboring gene putative GTPase NOG1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Downregulation of EHT1 and EEB1 in Saccharomyces cerevisiae Alters the Ester Profile of Wine during Fermentation. Yang X, et al. J Microbiol Biotechnol, 2022 Jun 28. PMID 35484971, Free PMC Article
  2. Controlled intracellular trafficking alleviates an expression bottleneck in S. cerevisiae ester biosynthesis. Zhu J, et al. Metab Eng Commun, 2019 Jun. PMID 30622894, Free PMC Article
  3. Parameters affecting ethyl ester production by Saccharomyces cerevisiae during fermentation. Saerens SM, et al. Appl Environ Microbiol, 2008 Jan. PMID 17993562, Free PMC Article
  4. The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. Saerens SM, et al. J Biol Chem, 2006 Feb 17. PMID 16361250
  5. Differential Analysis of Proteins Involved in Ester Metabolism in two Saccharomyces cerevisiae Strains during the Second Fermentation in Sparkling Wine Elaboration. González-Jiménez MDC, et al. Microorganisms, 2020 Mar 13. PMID 32183073, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of EHT1 and EEB1 in Saccharomyces cerevisiae Alters the Ester Profile of Wine during Fermentation.
    Title: Downregulation of EHT1 and EEB1 in Saccharomyces cerevisiae Alters the Ester Profile of Wine during Fermentation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol O-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alcohol O-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables monoacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables short-chain carboxylesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in medium-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in medium-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in medium-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in medium-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in medium-chain fatty acid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
medium-chain fatty acid ethyl ester synthase/esterase
NP_015230.1
  • Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    368071..369441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183909.1 → NP_015230.1  TPA: medium-chain fatty acid ethyl ester synthase/esterase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015230.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3S2, Q02891
    UniProtKB/TrEMBL
    C7GJ49, G2WP86, N1NVX0
    Conserved Domains (1) summary
    COG0429
    Location:38 → 456
    YheT; Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02891.1

Gene LinkOut

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