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MFM1 Mfm1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856045, updated on 2-Nov-2024

Summary

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Official Symbol
MFM1
Official Full Name
Mfm1p
Primary source
SGD:S000005981
Locus tag
YPL060W
See related
AllianceGenome:SGD:S000005981; FungiDB:YPL060W; VEuPathDB:YPL060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPE10
Summary
Enables magnesium ion transmembrane transporter activity. Involved in mitochondrial magnesium ion transmembrane transport. Located in mitochondrial inner membrane. Orthologous to human MRS2 (magnesium transporter MRS2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MFM1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (434523..435764)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene aldehyde dehydrogenase (NADP(+)) ALD6 Neighboring gene tRNA-Cys Neighboring gene gag-pol fusion protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A member of a novel Arabidopsis thaliana gene family of candidate Mg2+ ion transporters complements a yeast mitochondrial group II intron-splicing mutant. Schock I, et al. Plant J, 2000 Nov. PMID 11115130
  2. Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel. Sponder G, et al. FEBS J, 2010 Sep. PMID 20653776
  3. The mitochondrial inner membrane protein Lpe10p, a homologue of Mrs2p, is essential for magnesium homeostasis and group II intron splicing in yeast. Gregan J, et al. Mol Gen Genet, 2001 Feb. PMID 11254124
  4. A novel mitochondrial carrier protein Mme1 acts as a yeast mitochondrial magnesium exporter. Cui Y, et al. Biochim Biophys Acta, 2015 Mar. PMID 25585246
  5. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. Zsurka G, et al. Genomics, 2001 Mar 1. PMID 11401429

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interplay of Lpe10p is of central significance for the transport of Mg(2+) into mitochondria of S. cerevisiae.
    Title: Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial magnesium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial magnesium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mfm1p
NP_015265.1
  • Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    434523..435764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183874.1 → NP_015265.1  TPA: Mfm1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015265.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3V4, Q02783, Q6B1B1
    UniProtKB/TrEMBL
    C7GTZ6, G2WPB9
    Conserved Domains (1) summary
    cd12823
    Location:74 → 395
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02783.1

Gene LinkOut

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