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LGE1 Lge1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856052, updated on 3-Nov-2024

Summary

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Official Symbol
LGE1
Official Full Name
Lge1p
Primary source
SGD:S000005976
Locus tag
YPL055C
See related
AllianceGenome:SGD:S000005976; FungiDB:YPL055C; VEuPathDB:YPL055C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables molecular condensate scaffold activity. Involved in premeiotic DNA replication. Is active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LGE1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (453992..454990, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mannosylinositol phosphorylceramide synthase catalytic subunit SUR1 Neighboring gene Lcl1p Neighboring gene Lee1p Neighboring gene putative mannosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phase separation directs ubiquitination of gene-body nucleosomes. Gallego LD, et al. Nature, 2020 Mar. PMID 32214243, Free PMC Article
  2. H2B ubiquitination: Conserved molecular mechanism, diverse physiologic functions of the E3 ligase during meiosis. Wang L, et al. Nucleus, 2017 Sep 3. PMID 28628358, Free PMC Article
  3. Anethole potentiates dodecanol's fungicidal activity by reducing PDR5 expression in budding yeast. Fujita KI, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27632201
  4. Bre1 mediates the ubiquitination of histone H2B by regulating Lge1 stability. Kim J, et al. FEBS Lett, 2018 May. PMID 29637554
  5. Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination. Zhang X, et al. J Biol Chem, 2005 Jan 28. PMID 15528187

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bre1 mediates the ubiquitination of histone H2B by regulating Lge1 stability
    Title: Bre1 mediates the ubiquitination of histone H2B by regulating Lge1 stability.
  2. Lge1 has a novel function in disrupting the balance between the recruitment of Bre1 and Ubp8, thus promoting transcription elongation
    Title: A Bre1-associated protein, large 1 (Lge1), promotes H2B ubiquitylation during the early stages of transcription elongation.
  3. Lge1p has roles in gene regulation independent of its participation in the Rad6p-dependent ubiquitination of H2B
    Title: Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular condensate scaffold activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular condensate scaffold activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in premeiotic DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell size HMP PubMed 
Component Evidence Code Pubs
located_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Lge1p
NP_015270.1
  • Protein that facilitates co-transcriptional histone H2B ubiquitination; scaffold protein that promotes oligomerization of E3 ligase Bre1p; contains an intrinsically disordered region that phase separates, to form a core encapsulated by Bre1p that recruits Ub-conjugating enzyme Rad6p, elevating catalytic activity along gene bodies; null mutant forms abnormally large cells, and homozygous null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    453992..454990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183869.1 → NP_015270.1  TPA: Lge1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015270.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3V9, Q02796, Q6Q5I8
    UniProtKB/TrEMBL
    G2WPC3, N1NX97
    Conserved Domains (1) summary
    pfam11488
    Location:251 → 329
    Lge1; Transcriptional regulatory protein LGE1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02796.1

Gene LinkOut

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