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ARL3 Arf family GTPase ARL3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856056, updated on 2-Nov-2024

Summary

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Official Symbol
ARL3
Official Full Name
Arf family GTPase ARL3
Primary source
SGD:S000005972
Locus tag
YPL051W
See related
AllianceGenome:SGD:S000005972; FungiDB:YPL051W; VEuPathDB:YPL051W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity. Involved in protein localization to Golgi apparatus; protein transport; and response to endoplasmic reticulum stress. Located in Golgi apparatus and nuclear outer membrane-endoplasmic reticulum membrane network. Orthologous to human ARFRP1 (ADP ribosylation factor related protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ARL3 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (459963..460559)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative mannosyltransferase Neighboring gene Oaz1p Neighboring gene mannosyltransferase complex subunit MNN9 Neighboring gene Dig1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a novel ADP-ribosylation factor-like protein (yARL3) in Saccharomyces cerevisiae. Huang CF, et al. J Biol Chem, 1999 Feb 5. PMID 9920936
  2. Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3. Setty SR, et al. Curr Biol, 2003 Mar 4. PMID 12620188
  3. Competition between the golgin Imh1p and the GAP Gcs1p stabilizes activated Arl1p at the late-Golgi. Chen KY, et al. J Cell Sci, 2012 Oct 1. PMID 22767516
  4. The Arl3 and Arl1 GTPases co-operate with Cog8 to regulate selective autophagy via Atg9 trafficking. Wang IH, et al. Traffic, 2017 Sep. PMID 28627726
  5. Mutational analysis of the yeast TRAPP subunit Trs20p identifies roles in endocytic recycling and sporulation. Mahfouz H, et al. PLoS One, 2012. PMID 23049729, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atg9 accumulates at the late Golgi in arl3cog8Delta and arl1cog8Delta cells under normal growth conditions but not under starvation conditions
    Title: The Arl3 and Arl1 GTPases co-operate with Cog8 to regulate selective autophagy via Atg9 trafficking.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Arf family GTPase ARL3
NP_015274.1
  • ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    459963..460559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183865.1 → NP_015274.1  TPA: Arf family GTPase ARL3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015274.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3W3, Q02804
    UniProtKB/TrEMBL
    A6ZWJ7, B3LL16, B5VTA9, C7GU03, C8ZIX8, G2WPC7, N1NVY8
    Conserved Domains (1) summary
    cd04160
    Location:19 → 185
    Arfrp1; Arf-related protein 1 (Arfrp1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02804.1

Gene LinkOut

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