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DIG1 Dig1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856058, updated on 2-Nov-2024

Summary

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Official Symbol
DIG1
Official Full Name
Dig1p
Primary source
SGD:S000005970
Locus tag
YPL049C
See related
AllianceGenome:SGD:S000005970; FungiDB:YPL049C; VEuPathDB:YPL049C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RST1
Summary
Enables transcription corepressor activity. Involved in cellular response to pheromone; negative regulation of growth of unicellular organism as a thread of attached cells; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of Ste12p-Dig1p-Dig2p complex and Tec1p-Ste12p-Dig1p complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DIG1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (462481..463839, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Arf family GTPase ARL3 Neighboring gene mannosyltransferase complex subunit MNN9 Neighboring gene translation elongation factor EF1B gamma Neighboring gene SAGA histone acetyltransferase complex subunit SGF11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aneuploidy underlies a multicellular phenotypic switch. Tan Z, et al. Proc Natl Acad Sci U S A, 2013 Jul 23. PMID 23812752, Free PMC Article
  2. Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p. Pi H, et al. Mol Cell Biol, 1997 Nov. PMID 9343403, Free PMC Article
  3. Endogenous transcription at the centromere facilitates centromere activity in budding yeast. Ohkuni K, et al. Curr Biol, 2011 Oct 25. PMID 22000103, Free PMC Article
  4. Assigning quantitative function to post-translational modifications reveals multiple sites of phosphorylation that tune yeast pheromone signaling output. Pincus D, et al. PLoS One, 2013. PMID 23554854, Free PMC Article
  5. Identification and characterization of extragenic suppressors of the yeast sec12 ts mutation. Nakano A. J Biochem, 1996 Sep. PMID 8902631

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the transcriptional repressors Dig1 and Dig2 positively affect transcription by stabilizing Ste12
    Title: Positive roles for negative regulators in the mating response of yeast.
  2. Dig1 represses Ste12-dependent transcription at the centromere.
    Title: Endogenous transcription at the centromere facilitates centromere activity in budding yeast.
  3. Dig1 and Dig2 contribute to the retention of phosphorylated Fus3 in the nucleus.
    Title: The pheromone-induced nuclear accumulation of the Fus3 MAPK in yeast depends on its phosphorylation state and on Dig1 and Dig2.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to pheromone IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of invasive growth in response to glucose limitation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of pseudohyphal growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Ste12p-Dig1p-Dig2p complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Tec1p-Ste12p-Dig1p complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dig1p
NP_015276.1
  • MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG1 has a paralog, DIG2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    462481..463839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183863.1 → NP_015276.1  TPA: Dig1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015276.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3W5, Q03063
    UniProtKB/TrEMBL
    G2WPC9, N1P1R6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03063.1

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