CAM1 translation elongation factor EF1B gamma [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CAM1
Official Full Name: translation elongation factor EF1B gamma
Primary source: SGD:S000005969
Locus tag: YPL048W
See related: AllianceGenome:SGD:S000005969; FungiDB:YPL048W; VEuPathDB:YPL048W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TEF3
Summary: Enables several functions, including calcium ion binding activity; core promoter sequence-specific DNA binding activity; and guanyl-nucleotide exchange factor activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of translational termination; and translational elongation. Located in nucleus. Orthologous to human EEF1G (eukaryotic translation elongation factor 1 gamma). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CAM1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (464401..465648)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The two S. cerevisiae homologs of eEF1Bgamma encoded by TEF3 and TEF4 show significant amino acid divergence and are only 45% identical in their N-temrinal amino acids.
Title: The translation elongation factor eEF1B plays a role in the oxidative stress response pathway.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translational termination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IDA Inferred from Direct Assay more info	PubMed
involved_in translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: translation elongation factor EF1B gamma

NP_015277.1

One of two isoforms of the gamma subunit of eEF1B; stimulates the release of GDP from eEF1A (Tef1p/Tef2p) post association with the ribosomal complex with eEF1Balpha subunit; nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

464401..465648

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183862.1 → NP_015277.1 TPA: translation elongation factor EF1B gamma [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015277.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3W6, P29547, Q9URC6

UniProtKB/TrEMBL

A6ZWK0, B3LL19, B5VTB2, C7GU06, C8ZIY1, G2WPD0, N1NW49

Conserved Domains (3) summary

cd03181
Location:92 → 214

GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins

cd03044
Location:4 → 73

GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...

pfam00647
Location:255 → 359

EF1G; Elongation factor 1 gamma, conserved domain