SGF11 SAGA histone acetyltransferase complex subunit SGF11 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SGF11
Official Full Name: SAGA histone acetyltransferase complex subunit SGF11
Primary source: SGD:S000005968
Locus tag: YPL047W
See related: AllianceGenome:SGD:S000005968; FungiDB:YPL047W; VEuPathDB:YPL047W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables enzyme activator activity. Involved in regulation of transcription by RNA polymerase II. Located in nucleus. Part of DUBm complex and SAGA complex. Orthologous to human ATXN7L3 (ataxin 7 like 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SGF11 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (465962..466261)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA binding by Sgf11 protein affects histone H2B deubiquitination
Title: DNA binding by Sgf11 protein affects histone H2B deubiquitination by Spt-Ada-Gcn5-acetyltransferase (SAGA).
an unexpected role for Sgf11 in compensating for the absence of structural features that maintain the active conformation of Ubp8.
Title: A role for intersubunit interactions in maintaining SAGA deubiquitinating module structure and activity.
study reports the 1.90 angstrom resolution crystal structure of the deubiquitinating module (DUBm)- which contains Ubp8 bound to Sgf11, Sus1 and Sgf73- bound to ubiquitin aldehyde, as well as the 2.45 angstrom resolution structure of the uncomplexed DUBm
Title: Structural insights into the assembly and function of the SAGA deubiquitinating module.
Data show that the Sus1-binding site on Sgf11 is somewhat shorter than on Sac3 and is based on a narrower hydrophobic stripe.
Title: Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.
Thus, the Sus1-Sgf11-Ubp8 module could work at the junction between SAGA-dependent transcription and nuclear mRNA export.
Title: The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11.
Ubp8p differential control of H3-K4 methylation is mediated by Sgf11p at the SAGA-dependent promoters.
Title: Ubp8p, a histone deubiquitinase whose association with SAGA is mediated by Sgf11p, differentially regulates lysine 4 methylation of histone H3 in vivo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DUBm complex	IDA Inferred from Direct Assay more info	PubMed
part_of DUBm complex	IEA Inferred from Electronic Annotation more info
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	IEA Inferred from Electronic Annotation more info
part_of SAGA-type complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SAGA histone acetyltransferase complex subunit SGF11

NP_015278.1

Integral subunit of SAGA histone acetyltransferase complex; regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

465962..466261

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183861.1 → NP_015278.1 TPA: SAGA histone acetyltransferase complex subunit SGF11 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015278.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZWK1, B3LL20, D6W3W7, Q03067

UniProtKB/TrEMBL

C7GU07, C8ZIY2, G2WPD1, N1NXA6

Conserved Domains (2) summary

pfam08209
Location:67 → 99

Sgf11; Sgf11 (transcriptional regulation protein)

pfam18519
Location:6 → 44

Sgf11_N; SAGA-associated factor 11 N-terminal domain