VPS16 tethering complex subunit VPS16 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: VPS16
Official Full Name: tethering complex subunit VPS16
Primary source: SGD:S000005966
Locus tag: YPL045W
See related: AllianceGenome:SGD:S000005966; FungiDB:YPL045W; VEuPathDB:YPL045W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CVT15; SVL6; VAM9; VPT16
Summary: Contributes to phosphatidylinositol binding activity. Involved in several processes, including Golgi to endosome transport; vacuolar transport; and vacuole fusion, non-autophagic. Located in fungal-type vacuole membrane. Part of CORVET complex and HOPS complex. Human ortholog(s) of this gene implicated in dystonia 30. Orthologous to human VPS16 (VPS16 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in late endosome to vacuole transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of SNARE complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in vacuole fusion, non-autophagic	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuole fusion, non-autophagic	IDA Inferred from Direct Assay more info	PubMed
involved_in vacuole fusion, non-autophagic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuole organization	IEA Inferred from Electronic Annotation more info
involved_in vacuole organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle tethering	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of CORVET complex	IDA Inferred from Direct Assay more info	PubMed
part_of HOPS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of HOPS complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

NP_015280.1

Subunit of the HOPS and the CORVET complexes; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages

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