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SRL4 Srl4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856074, updated on 2-Nov-2024

Summary

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Official Symbol
SRL4
Official Full Name
Srl4p
Primary source
SGD:S000005954
Locus tag
YPL033C
See related
AllianceGenome:SGD:S000005954; FungiDB:YPL033C; VEuPathDB:YPL033C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in deoxyribonucleoside triphosphate metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SRL4 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (487362..488207, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene H(+)-exporting P2-type ATPase PMA2 Neighboring gene uncharacterized protein Neighboring gene Svl3p Neighboring gene cyclin-dependent serine/threonine-protein kinase PHO85

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mutation of a novel Saccharomyces cerevisiae SRL4 gene rescues the lethality of rad53 and lcd1 mutations by modulating dNTP levels. Choi DH, et al. J Microbiol, 2008 Feb. PMID 18337697
  2. Yeast and human genes that affect the Escherichia coli SOS response. Perkins EL, et al. Proc Natl Acad Sci U S A, 1999 Mar 2. PMID 10051619, Free PMC Article
  3. Role of transcription factor Kar4 in regulating downstream events in the Saccharomyces cerevisiae pheromone response pathway. Lahav R, et al. Mol Cell Biol, 2007 Feb. PMID 17101777, Free PMC Article
  4. A screen for spore wall permeability mutants identifies a secreted protease required for proper spore wall assembly. Suda Y, et al. PLoS One, 2009 Sep 25. PMID 19779569, Free PMC Article
  5. A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast. Lam C, et al. Eukaryot Cell, 2014 Mar. PMID 24390141, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRL4 (YPL033C) may be involved in the regulation of dNTP production by its function as a negative regulator of ribonucleotide reductase.
    Title: The mutation of a novel Saccharomyces cerevisiae SRL4 gene rescues the lethality of rad53 and lcd1 mutations by modulating dNTP levels.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in deoxyribonucleoside triphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
Srl4p
NP_015292.1
  • hypothetical protein; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    487362..488207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183847.1 → NP_015292.1  TPA: Srl4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015292.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Y0, Q03085
    UniProtKB/TrEMBL
    A6ZWL4, B5VTC7, C8ZIZ6, G2WPE5, N1P1S9
    Conserved Domains (1) summary
    cl21454
    Location:28 → 223
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03085.1

Gene LinkOut

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