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ERG10 acetyl-CoA C-acetyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856079, updated on 3-Nov-2024

Summary

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Official Symbol
ERG10
Official Full Name
acetyl-CoA C-acetyltransferase
Primary source
SGD:S000005949
Locus tag
YPL028W
See related
AllianceGenome:SGD:S000005949; FungiDB:YPL028W; VEuPathDB:YPL028W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPB3; TSM0115
Summary
Enables acetyl-CoA C-acetyltransferase activity. Involved in ergosterol biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ERG10 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (498096..499292)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA (uracil) methyltransferase Neighboring gene ATP-dependent RNA helicase SUV3 Neighboring gene Sma1p Neighboring gene putative serine/threonine protein kinase SKS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, sequencing and analysis of the yeast S. uvarum ERG10 gene encoding acetoacetyl CoA thiolase. Dequin S, et al. Curr Genet, 1988 Jun. PMID 2900076
  2. Two forms of acetoacetyl coenzyme A thiolase in yeast. I. Separation and properties. Kornblatt JA, et al. J Biol Chem, 1971 Jul 25. PMID 5571829
  3. Two forms of acetoacetyl coenzyme A thiolase in yeast. II. Intracellular location and relationship to growth. Kornblatt JA, et al. J Biol Chem, 1971 Jul 25. PMID 5571830
  4. ERG10 from Saccharomyces cerevisiae encodes acetoacetyl-CoA thiolase. Hiser L, et al. J Biol Chem, 1994 Dec 16. PMID 7989303
  5. Transcriptional regulation of a sterol-biosynthetic enzyme by sterol levels in Saccharomyces cerevisiae. Dimster-Denk D, et al. Mol Cell Biol, 1996 Aug. PMID 8754796, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structures of apo ERG10 and its Cys91Ala variant were solved at resolutions of 2.2 and 1.95 A, respectively. ERG10 shares the characteristic thiolase superfamily fold, with a similar active-site architecture to those of type II thiolases and a similar binding pocket, apart from Ala159 at the entrance to the pantetheine-binding cavity, which appears to be a determinant of the poor binding ability of the substrate.
    Title: Crystal structure of cytoplasmic acetoacetyl-CoA thiolase from Saccharomyces cerevisiae.
  2. Erg10 thiolase from Saccharomyces cerevisiae showed no acetyl-CoA/butyryl-CoA branched condensation activity, but variants at position F293 resulted the most active and selective biocatalysts for this reaction.
    Title: Engineering Erg10 Thiolase from Saccharomyces cerevisiae as a Synthetic Toolkit for the Production of Branched-Chain Alcohols.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetyl-CoA C-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetyl-CoA C-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetyl-CoA C-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in vacuole NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
acetyl-CoA C-acetyltransferase
NP_015297.1
  • Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; human ACAT1 functionally complements the growth defect caused by repression of ERG10 expression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    498096..499292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183842.1 → NP_015297.1  TPA: acetyl-CoA C-acetyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015297.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Y5, P41338
    UniProtKB/TrEMBL
    A6ZWL9, B3LL36, B5VTD5, C7GU24, C8ZJ01, G2WPF1, N1NW56
    Conserved Domains (1) summary
    PLN02644
    Location:4 → 396
    PLN02644; acetyl-CoA C-acetyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41338.3

Gene LinkOut

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