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ERG10 acetyl-CoA C-acetyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856079, updated on 2-Nov-2024

Summary

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Official Symbol
ERG10
Official Full Name
acetyl-CoA C-acetyltransferase
Primary source
SGD:S000005949
Locus tag
YPL028W
See related
AllianceGenome:SGD:S000005949; FungiDB:YPL028W; VEuPathDB:YPL028W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPB3; TSM0115
Summary
Enables acetyl-CoA C-acetyltransferase activity. Involved in ergosterol biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ERG10 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (498096..499292)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA (uracil) methyltransferase Neighboring gene ATP-dependent RNA helicase SUV3 Neighboring gene Sma1p Neighboring gene putative serine/threonine protein kinase SKS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pyridines and pyrimidines mediating activity against an efflux-negative strain of Candida albicans through putative inhibition of lanosterol demethylase. Buurman ET, et al. Antimicrob Agents Chemother, 2004 Jan. PMID 14693556, Free PMC Article
  2. Transcriptional regulation of a sterol-biosynthetic enzyme by sterol levels in Saccharomyces cerevisiae. Dimster-Denk D, et al. Mol Cell Biol, 1996 Aug. PMID 8754796, Free PMC Article
  3. Crystal structure of cytoplasmic acetoacetyl-CoA thiolase from Saccharomyces cerevisiae. Zhou P, et al. Acta Crystallogr F Struct Biol Commun, 2018 Jan 1. PMID 29372902, Free PMC Article
  4. ERG10 from Saccharomyces cerevisiae encodes acetoacetyl-CoA thiolase. Hiser L, et al. J Biol Chem, 1994 Dec 16. PMID 7989303
  5. Engineering Erg10 Thiolase from Saccharomyces cerevisiae as a Synthetic Toolkit for the Production of Branched-Chain Alcohols. Torres-Salas P, et al. Biochemistry, 2018 Feb 27. PMID 29360348

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structures of apo ERG10 and its Cys91Ala variant were solved at resolutions of 2.2 and 1.95 A, respectively. ERG10 shares the characteristic thiolase superfamily fold, with a similar active-site architecture to those of type II thiolases and a similar binding pocket, apart from Ala159 at the entrance to the pantetheine-binding cavity, which appears to be a determinant of the poor binding ability of the substrate.
    Title: Crystal structure of cytoplasmic acetoacetyl-CoA thiolase from Saccharomyces cerevisiae.
  2. Erg10 thiolase from Saccharomyces cerevisiae showed no acetyl-CoA/butyryl-CoA branched condensation activity, but variants at position F293 resulted the most active and selective biocatalysts for this reaction.
    Title: Engineering Erg10 Thiolase from Saccharomyces cerevisiae as a Synthetic Toolkit for the Production of Branched-Chain Alcohols.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetyl-CoA C-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetyl-CoA C-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetyl-CoA C-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in vacuole NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
acetyl-CoA C-acetyltransferase
NP_015297.1
  • Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; human ACAT1 functionally complements the growth defect caused by repression of ERG10 expression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    498096..499292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183842.1 → NP_015297.1  TPA: acetyl-CoA C-acetyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015297.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Y5, P41338
    UniProtKB/TrEMBL
    A6ZWL9, B3LL36, B5VTD5, C7GU24, C8ZJ01, G2WPF1, N1NW56
    Conserved Domains (1) summary
    PLN02644
    Location:4 → 396
    PLN02644; acetyl-CoA C-acetyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41338.3

Gene LinkOut

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