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SKS1 putative serine/threonine protein kinase SKS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856081, updated on 2-Nov-2024

Summary

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Official Symbol
SKS1
Official Full Name
putative serine/threonine protein kinase SKS1
Primary source
SGD:S000005947
Locus tag
YPL026C
See related
AllianceGenome:SGD:S000005947; FungiDB:YPL026C; VEuPathDB:YPL026C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SHA3
Summary
Enables protein kinase activity. Involved in positive regulation of transcription by RNA polymerase II; pseudohyphal growth; and regulation of D-glucose transmembrane transport. Located in nucleus. Orthologous to several human genes including TSSK1B (testis specific serine kinase 1B); TSSK2 (testis specific serine kinase 2); and TSSK3 (testis specific serine kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SKS1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (500675..502183, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene acetyl-CoA C-acetyltransferase Neighboring gene Sma1p Neighboring gene Rmi1p Neighboring gene methylenetetrahydrofolate reductase (NAD(P)H) MET12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Nuclear Zip Code in SKS1 mRNA Promotes Its Slow Export, Nuclear Retention, and Degradation by the Nuclear Exosome/DRN in Saccharomyces cerevisiae. Das S, et al. J Mol Biol, 2019 Sep 6. PMID 31295459
  2. The SKS1 gene of Saccharomyces cerevisiae is required for long-term adaptation of snf3 null strains to low glucose. Vagnoli P, et al. Yeast, 1998 Mar 15. PMID 9559544
  3. Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast. Hepowit NL, et al. Elife, 2020 Oct 19. PMID 33074099, Free PMC Article
  4. A new laboratory evolution approach to select for constitutive acetic acid tolerance in Saccharomyces cerevisiae and identification of causal mutations. González-Ramos D, et al. Biotechnol Biofuels, 2016. PMID 27525042, Free PMC Article
  5. The SKS1 protein kinase is a multicopy suppressor of the snf3 mutation of Saccharomyces cerevisiae. Yang Z, et al. Yeast, 1996 Nov. PMID 8948096

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of D-glucose transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative serine/threonine protein kinase SKS1
NP_015299.1
  • Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog, VHS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    500675..502183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183840.1 → NP_015299.1  TPA: putative serine/threonine protein kinase SKS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015299.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Y7, Q12505
    UniProtKB/TrEMBL
    G2WPF3, N1NVZ5
    Conserved Domains (1) summary
    cl21453
    Location:9 → 331
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12505.1

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