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RET3 coatomer subunit zeta [ Saccharomyces cerevisiae S288C ]

Gene ID: 856097, updated on 3-Nov-2024

Summary

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Official Symbol
RET3
Official Full Name
coatomer subunit zeta
Primary source
SGD:S000005931
Locus tag
YPL010W
See related
AllianceGenome:SGD:S000005931; FungiDB:YPL010W; VEuPathDB:YPL010W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Part of COPI vesicle coat. Orthologous to several human genes including COPZ2 (COPI coat complex subunit zeta 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RET3 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (535018..535587)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mRNA-binding protein RRP12 Neighboring gene Taf3p Neighboring gene Rqc2p Neighboring gene DNA helicase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and functional characterization of yeast zeta-COP. Yamazaki S, et al. J Biochem, 1997 Jan. PMID 9058184
  2. Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval. Cosson P, et al. EMBO J, 1996 Apr 15. PMID 8617224, Free PMC Article
  3. Full-length structural model of RET3 and SEC21 in COPI: identification of binding sites on the appendage for accessory protein recruitment motifs. Alisaraie L, et al. J Mol Model, 2012 Jul. PMID 22246286, Free PMC Article
  4. Molecular structure and flexibility of the yeast coatomer as revealed by electron microscopy. Yip CK, et al. J Mol Biol, 2011 May 20. PMID 21435344, Free PMC Article
  5. Alpha-COP can discriminate between distinct, functional di-lysine signals in vitro and regulates access into retrograde transport. Schröder-Köhne S, et al. J Cell Sci, 1998 Dec. PMID 9811561

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPI vesicle coat IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COPI vesicle coat IEA
Inferred from Electronic Annotation
more info
  
part_of COPI vesicle coat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in COPI-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coatomer subunit zeta
NP_015315.1
  • Zeta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    535018..535587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183824.1 → NP_015315.1  TPA: coatomer subunit zeta [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015315.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W402, P53600
    UniProtKB/TrEMBL
    A6ZWN6, B3LL52, B5VTF2, C7GU40, C8ZJ17, G2WPH0, N1NVI8
    Conserved Domains (1) summary
    COG5541
    Location:3 → 189
    RET3; Vesicle coat complex COPI, zeta subunit [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53600.1

Gene LinkOut

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