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MRX21 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856121, updated on 11-Sep-2024

Summary

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Official Symbol
MRX21
Primary source
SGD:S000006215
Locus tag
YPR011C
See related
AllianceGenome:SGD:S000006215; FungiDB:YPR011C; VEuPathDB:YPR011C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity and 5'-adenylyl sulfate transmembrane transporter activity. Involved in 3'-phospho-5'-adenylyl sulfate transmembrane transport and 5'-adenylyl sulfate transmembrane transport. Located in mitochondrion. Orthologous to human SLC25A16 (solute carrier family 25 member 16) and SLC25A42 (solute carrier family 25 member 42). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (583062..584042, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene Mra1p Neighboring gene Cmr3p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Saccharomyces cerevisiae gene YPR011c encodes a mitochondrial transporter of adenosine 5'-phosphosulfate and 3'-phospho-adenosine 5'-phosphosulfate. Todisco S, et al. Biochim Biophys Acta, 2014 Feb. PMID 24296033
  2. The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with other proteins. Belenkiy R, et al. Biochim Biophys Acta, 2000 Jul 31. PMID 10930523
  3. Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. Vizeacoumar FJ, et al. J Cell Biol, 2010 Jan 11. PMID 20065090, Free PMC Article
  4. Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis. Singh AP, et al. Mol Cell, 2020 Sep 17. PMID 32877643
  5. Mapping pathways and phenotypes by systematic gene overexpression. Sopko R, et al. Mol Cell, 2006 Feb 3. PMID 16455487

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-adenylyl sulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 3'-phospho-5'-adenylyl sulfate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 5'-adenylyl sulfate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenine nucleotide transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mrx21p
NP_015336.1
  • Mitochondrial transporter; major substrates are adenosine 5'-phosphosulfate (APS) and 3'-phospho-adenosine 5'-phosphosulfate (PAPS); member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    583062..584042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184108.1 → NP_015336.1  TPA: Mrx21p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015336.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W423, Q12251
    UniProtKB/TrEMBL
    B3LL72, B5VTH2, C7GV37, N1NXF8
    Conserved Domains (1) summary
    PTZ00169
    Location:26 → 304
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12251.1

Gene LinkOut

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